Voluntary exercise improves metabolic profile in high-fat fed glucocorticoid-treated rats

Journal of Applied Physiology
Jacqueline L BeaudryMichael C Riddell

Abstract

Diabetes is rapidly induced in young male Sprague-Dawley rats following treatment with exogenous corticosterone (CORT) and a high-fat diet (HFD). Regular exercise alleviates insulin insensitivity and improves pancreatic β-cell function in insulin-resistant/diabetic rodents, but its effect in an animal model of elevated glucocorticoids is unknown. We examined the effect of voluntary exercise (EX) on diabetes development in CORT-HFD-treated male Sprague-Dawley rats (∼6 wk old). Animals were acclimatized to running wheels for 2 wk, then given a HFD, either wax (placebo) or CORT pellets, and split into 4 groups: placebo-sedentary (SED) or -EX and CORT-SED or -EX. After 2 wk of running combined with treatment, CORT-EX animals had reduced visceral adiposity, and increased skeletal muscle type IIb/x fiber area, oxidative capacity, capillary-to-fiber ratio and insulin sensitivity compared with CORT-SED animals (all P < 0.05). Although CORT-EX animals still had fasting hyperglycemia, these values were significantly improved compared with CORT-SED animals (14.3 ± 1.6 vs. 18.8 ± 0.9 mM). In addition, acute in vivo insulin response to an oral glucose challenge was enhanced ∼2-fold in CORT-EX vs. CORT-SED (P < 0.05) which was further demons...Continue Reading

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Citations

Feb 6, 2020·Experimental Physiology·Michelle CurranParth Narendran
Nov 12, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Emily C DunfordMichael C Riddell
Jan 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Gretha J BoersmaNu-Chu Liang
Jul 15, 2017·The Journal of Endocrinology·Thanh Q DangGary Sweeney
Oct 18, 2020·International Journal of Molecular Sciences·Jonatan DassonvalleRodrigo Troncoso

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