Voluntary exercise offers anxiolytic potential and amplifies galanin gene expression in the locus coeruleus of the rat.

Behavioural Brain Research
Natale R SciolinoPhilip V Holmes

Abstract

Although exercise improves anxiety in humans, it is controversial whether exercise is anxiolytic in rodents. We tested the hypothesis that stress influences the effect of exercise on anxiety-like and defensive behaviors. To explore the neurobiological mechanisms of exercise, we also examined whether exercise alters gene expression for the stress-related peptide galanin. Rats were housed in the presence or absence of a running wheel for 21 d. A subset of these rats were (1) not injected or received a single high, dose of the β-carboline FG7142 (inverse agonist at the benzodiazepine receptor site) immediately prior to testing or (2) were injected repeatedly with vehicle or FG7142 during the last 10d of exercise. On day 22, anxiety-like and defensive behaviors were measured in the elevated plus maze, shock probe defensive burying, and defensive withdrawal tests. Locus coeruleus prepro-galanin mRNA was measured by in situ hybridization. Exercise and sedentary rats that were not injected exhibited similar behavior in all tests, whereas FG7142 injected immediately prior to the test battery produced intense avoidance and immobility consistent with an anxiety-like response. However, exercise produced anxiolytic-like and active defensiv...Continue Reading

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Citations

Mar 4, 2014·Pharmacology, Biochemistry, and Behavior·Penghua FangZhenwen Zhang
Nov 21, 2015·Experimental Gerontology·Penghua FangZhenwen Zhang
Nov 27, 2015·Brain Research·David Weinshenker, Philip V Holmes
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Aug 1, 2015·Physiology & Behavior·Dilek OzbeyliOzgur Kasimay
Nov 6, 2012·The European Journal of Neuroscience·Benjamin N GreenwoodMonika Fleshner
Aug 9, 2015·Mechanisms of Ageing and Development·Zhenwen ZhangPing Bo
Jun 13, 2015·Journal of Molecular Psychiatry·Julie A MorganBernhard T Baune
Jul 10, 2012·Neuroscience and Biobehavioral Reviews·Natale R Sciolino, Philip V Holmes
Feb 3, 2016·The European Journal of Neuroscience·Jonathan J HerreraBenjamin N Greenwood
Jul 28, 2016·Proceedings of the National Academy of Sciences of the United States of America·Peng WangZhi-Qing David Xu
Nov 28, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Brendan D HareWilliam A Falls
Jan 21, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jean-Jacques HublinPhilipp Gunz
Apr 13, 2019·Scientific Reports·April E RoncaRuth K Globus
Apr 19, 2020·Molecular Brain·Arkadiusz LiśkiewiczMichal Toborek
May 4, 2017·Molecular Neurobiology·Karim A Alkadhi
Jan 11, 2019·Frontiers in Neural Circuits·Tomas HökfeltSven Ove Ögren
Jun 11, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yutao YangZhi-Qing David Xu

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