Abstract
MicroRNAs (miRNAs) may be important mediators of the profound molecular and cellular changes that occur after traumatic brain injury (TBI). However, the changes and possible roles of miRNAs induced by voluntary exercise prior to TBI are still not known. In this report, the microarray method was used to demonstrate alterations in miRNA expression levels in the cerebral cortex of TBI mice that were pretrained on a running wheel (RW). Voluntary RW exercise prior to TBI: i) significantly decreased the mortality rate and improved the recovery of the righting reflex in TBI mice, and ii) differentially changed the levels of several miRNAs, upregulating some and downregulating others. Furthermore, we revealed global upregulation of miR-21, miR-92a, and miR-874 and downregulation of miR-138, let-7c, and miR-124 expression among the sham-non-runner, TBI-non-runner, and TBI-runner groups. Quantitative reverse transcription polymerase chain reaction data (RT-qPCR) indicated good consistency with the microarray results. Our microarray-based analysis of miRNA expression in mice cerebral cortex after TBI revealed that some miRNAs such as miR-21, miR-92a, miR-874, miR-138, let-7c, and miR-124 could be involved in the prevention and protection ...Continue Reading
References
Apr 8, 2004·Brain : a Journal of Neurology·Karen J HutchinsonD Michele Basso
Nov 19, 2004·The European Journal of Neuroscience·Shoshanna VaynmanFernando Gomez-Pinilla
Aug 2, 2008·Neuroscience·Z YingF Gomez-Pinilla
Nov 21, 2008·Journal of Neuroscience Research·John B RedellPramod K Dash
Jun 9, 2009·Brain Research·Ping LeiJianning Zhang
Jun 27, 2009·Brain Research·Grace Sophia GriesbachFernando Gomez-Pinilla
Sep 4, 2009·Critical Care Medicine·Linda PapaKevin K W Wang
Mar 11, 2010·The Journal of Trauma·Stanislav I SvetlovKevin K W Wang
Oct 5, 2010·Journal of Neurotrauma·John B RedellPramod K Dash
Dec 31, 2010·Hippocampus·Susanna RosiJohn R Fike
Mar 29, 2011·Journal of Neural Transmission·Tatsuki ItohTakao Satou
May 11, 2012·The Journal of Head Trauma Rehabilitation·Sharon B Shively, Daniel P Perl
Jun 2, 2012·Science·Rubia van den BrandGrégoire Courtine
Jun 16, 2012·Biochimica Et Biophysica Acta·Weihong HouHerbert L Bonkovsky
Jul 5, 2012·PloS One·Zhonghua HuZheng Li
Dec 15, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Oneil G BhalalaJohn A Kessler
Apr 17, 2013·Nature Reviews. Neurology·Oneil G BhalalaJohn A Kessler
May 31, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yasuo OuchiTakashi Iwamoto
Jul 17, 2013·Advances in Nutrition·Stefan M Pasiakos, James P McClung
Aug 21, 2013·Brain Research·Jessie S TruettnerW Dalton Dietrich
Aug 21, 2013·Journal of Applied Physiology·Sébastien BanzetNathalie Koulmann
Sep 24, 2013·Nucleic Acids Research·Jie LiNingsheng Shao
Oct 29, 2013·Sports Medicine·Joshua DenhamFadi J Charchar
Nov 22, 2013·Journal of Physical Therapy Science·Hyun Mo KooMin Hee Kim
Dec 18, 2013·Journal of Molecular Neuroscience : MN·Xi GuXuemin Wang
Jun 13, 2014·Journal of Molecular Neuroscience : MN·Tian-Hao BaoYu-Hong Zhu
Citations
Apr 3, 2016·Neuroscience Bulletin·Songlin ZhouXiaosong Gu
Nov 8, 2016·Brain Injury : [BI]·Raghavendar ChandranRadha K Maheshwari
Apr 4, 2017·Acta Physiologica·J Denham
Jan 31, 2017·Neurochemistry International·Raghavendar ChandranRaghu Vemuganti
May 10, 2017·Journal of Neurotrauma·Bilal A MateenDavid K Menon
Jan 19, 2016·Brain Research·Lisa A Kreber, Grace S Griesbach
Dec 15, 2017·Neural Regeneration Research·Bridget Martinez, Philip V Peplow
Apr 27, 2018·Journal of Neurotrauma·Xintong GeJianning Zhang
Jul 3, 2018·Frontiers in Neurology·Valentina Di PietroAntonio Belli
Aug 30, 2018·Cellular and Molecular Life Sciences : CMLS·Niina VuokilaNoora Puhakka
Aug 2, 2018·Neurochemical Research·Wei JiJunfei Shao
Jul 18, 2020·International Journal of Molecular Sciences·Alex Cleber Improta-CariaBruno Solano de Freitas Souza
May 11, 2020·Neuromolecular Medicine·Lei ZhangNan Chi
Mar 20, 2019·Journal of Experimental Neuroscience·Hamna Atif, Steven D Hicks
Apr 5, 2020·International Journal of Molecular Sciences·Niina VuokilaAsla Pitkänen
Nov 18, 2020·The Journal of Head Trauma Rehabilitation·Amy A HerroldTheresa L Bender Pape
Jun 10, 2021·Nature Reviews. Drug Discovery·Carolina Gubert, Anthony J Hannan
Jul 24, 2021·Cerebral Cortex Communications·Yufen ChenUNKNOWN Concussion Neuroimaging Consortium