PMID: 1203626Nov 1, 1975Paper

Voluntary lithium intake, antidotal thirst' and concurrent behavior of rats

British Journal of Pharmacology
R J LanghamL A Syme

Abstract

1 Voluntary intake of various pair combinations of fluids (100 mM, 10 mM LiC1, 10 mM NaC1, water) and body weight was measured daily in rats. 2 More lithium was consumed when water was available. 3 When offered a lithium-sodium choice the rats did not consume significantly more saline than water on the previous trial. While saline consumption increased over the two days, lithium decreased slightly. 4 Following the lithium-only trial, water and saline were provided. Marked polydipsia was observed on the first day and the rats drank more water than saline. On the second day there was a significant drop in saline intake while water consumption returned to baseline levels. 5 Behavioural measurements overall confirmed the depressant effect of lithium: decreased ambulation and rearing and increased time spent immobile/grooming. 6 These findings are discussed with reference to lithium toxicity, which may be a comfounding variable in studies concerned with the effects of this salt on the behavior of laboratory rodents. Behavioural irritability such as aggression reported in situations using long-term lithium treatment may be reduced by provision for voluntary saline consumption.

References

Oct 1, 1974·Acta Pharmacologica Et Toxicologica·K ThomsenO V Olesen
Feb 2, 1972·Nature: New Biology·F N Johnson, S Wormington
May 1, 1973·Animal Behaviour·J Archer
Feb 27, 1973·Psychopharmacologia·L A Syme, G J Syme
Aug 1, 1973·Toxicology and Applied Pharmacology·G L Ellman, G L Gan
Jan 1, 1973·Acta Pharmacologica Et Toxicologica·K Thomsen
Jul 30, 1971·Nature·C CoxM Tomkiewicz
Dec 1, 1971·Acta Endocrinologica·V Schreiber, J Rohácová
Jul 28, 1971·Nature: New Biology·P E Harrison-Read, H Steinberg
Jan 16, 1970·Science·D F SmithM Lubran
Nov 1, 1953·Journal of Neurophysiology·L M BEIDLER

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Citations

May 29, 2007·Neuroscience and Biobehavioral Reviews·Kelley C O'Donnell, Todd D Gould

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