PMID: 7542854Sep 1, 1995Paper

Volunteer blood donors with antibody to hepatitis C virus: clinical, biochemical, virologic, and histologic features. The Hepatitis C Study Group

Annals of Internal Medicine
A O ShakilA M Di Bisceglie

Abstract

To assess the clinical significance of antibody to hepatitis C virus (anti-HCV) in volunteer blood donors. Prospective cohort study. National Institutes of Health Clinical Center, a tertiary referral research hospital. 60 anti-HCV-positive blood donors, divided into three groups of 20 persons each: Group I had normal alanine aminotransferase levels, group II had levels elevated to values less than twice the normal range, and group III had levels elevated to values greater than twice the normal range. Medical history, results of laboratory and virologic testing, and percutaneous liver biopsy findings. Participants with normal alanine aminotransferase levels were older and more often female than those with abnormal levels. The source of infection, duration of disease, symptom score, and amount of alcohol consumed were similar in the three groups. Hepatitis C virus RNA was detectable in 85% of participants, more commonly in the groups with elevated alanine aminotransferase levels (95%) than in the group with normal levels (65%); however, titers were similar in all groups. Examination of liver biopsy specimens showed chronic hepatitis in 54 participants (90%) and cirrhosis in 1 participant. The only normal liver biopsy specimens (n...Continue Reading

Citations

Mar 21, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A SangiovanniG Minoli
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J HeathcoteL M Blatt
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T V InglesbyD L Thomas
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T R FriedenK J Henning
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S A VillanoD L Thomas
May 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S E BassettR E Lanford
Jan 29, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P Saiz de la HoyaUNKNOWN Prevalhep study group
May 11, 2004·Current Diabetes Reports·Gül BahtiyarSamy I McFarlane
Feb 1, 2000·The American Journal of Medicine·A M Di Bisceglie
May 1, 1997·Obstetrics and Gynecology·C M HuntA I Sharara
Nov 27, 1999·Obstetrics and Gynecology·D N Burns, H Minkoff
Jul 4, 1998·Lancet·A M Di Bisceglie
Feb 20, 2003·Journal of Hepatology·Alfredo Alberti, Luisa Benvegnù
Jan 6, 2000·Journal of Hepatology·P Marcellin
Jan 6, 2000·Journal of Hepatology·N C Tassopoulos
Jan 6, 2001·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C PuotiF Montagnese
Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·C PuotiUNKNOWN Committee on HCV carriers with normal alanine aminotransferase levels of the Italian Association for the Study of the Liver
Aug 2, 2000·Journal of Gastroenterology and Hepatology·J M KaldorP K Correll
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A J FreemanJ M Kaldor
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pierre PradatChristian Trépo
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jay H Hoofnagle
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jules L Dienstag
Jun 27, 1996·The New England Journal of Medicine·C Conry-CantilenaJ W Shih
Jan 30, 1997·The New England Journal of Medicine·J H Hoofnagle, A M di Bisceglie
Oct 12, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P M Rosenberg
May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Nicholas C TassopoulosAngelos E Hatzakis
May 22, 2001·AIDS Patient Care and STDs·C A Sabin
Jun 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samer S El-KamaryMichelle D Shardell
Mar 12, 1999·Clinical Obstetrics and Gynecology·N L Eriksen
Jul 15, 1999·Journal of Clinical Gastroenterology·H ZylberbergP Berthelot
Mar 7, 2002·Journal of Pediatric Hematology/oncology·D K StricklandM M Hudson

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