PMID: 9442450Jan 27, 1998Paper

Vomiting induction by ipecac syrup in dogs and ferrets

The Journal of Toxicological Sciences
M YamashitaY Fujii

Abstract

The dog has been used as an experimental animal in emesis research. In this study, we analyzed the emetic effects of ipecac syrup using a smaller animal, the ferret, and compared its response to that of the dog. Dogs and ferrets were divided into 4 groups (n = 4, each). Each group was given either 0.1, 0.25, 0.5, or 1.0 ml/kg of ipecac syrup, and the latency and numbers of retching and vomiting were recorded. Animals given an equal volume of saline served as controls. The numbers of vomiting and retching increased dose-dependently in both dogs and ferrets, and there was no difference in latency and numbers of vomiting between them. The numbers of retching were greater in ferrets than in dogs at > or = 0.25 ml/kg. Taking these results into consideration, the ferret seems to be as useful as the dog in studies on emetic effects of ipecac syrup.

Citations

Aug 1, 2012·Oxidative Medicine and Cellular Longevity·Antonios KyparosIoannis S Vrabas
Jan 6, 2009·BMC Neuroscience·Henry R CostantinoSteven C Quay
Mar 12, 2011·Expert Opinion on Drug Delivery·Antonio Di StefanoPiera Sozio
Apr 15, 2008·The Veterinary Clinics of North America. Exotic Animal Practice·Eric Dunayer
Dec 19, 2006·International Journal of Pharmaceutics·Alexis Kays LeonardHenry R Costantino

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