Von Hippel-Lindau tumour suppressor gene. Localization of expression by in situ hybridization

The Journal of Pathology
Yoji NagashimaT Shuin

Abstract

Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene is responsible not only for VHL disease, but also for sporadic renal cell carcinoma and cerebellar haemangioblastoma. The distribution of VHL gene expression in the mouse embryo was recently studied by in situ hybridization, along with human VHL in 14-week-old fetal kidney: there was widely distributed expression in the former and expression in the tubules and blastema in the latter. Adult human tissue and other fetal organs were not examined. The present paper describes an in situ hybridization study to assess the function of the VHL gene in adult human tissues and in tissues of human fetus at 28 weeks of gestation. The expression of the VHL gene was limited to the adult and fetal brain and kidney, and the adult prostate. Nerve cells in adult and fetal brain were positive, including the cerebellar Purkinje cells. In adult and fetal kidney, the proximal tubular epithelium, the putative origin of the common type of renal cell carcinoma, showed intense signal, whereas the distal nephron, glomeruli, and nephrogenic blastema showed no significant signal. The prostate showed significant signal in the basal epithelium. The adrenal, pancreas, and epidydimis showed no s...Continue Reading

References

Dec 11, 1975·Proceedings of the National Academy of Sciences of the United States of America·A G KnudsonB W Brown
Jan 1, 1990·European Urology·W ThoenesR Moll
Sep 1, 1988·Human Pathology·D Solomon, A Schwartz
Aug 1, 1995·Nature Medicine·O IliopoulosW G Kaelin
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·D R DuanR D Klausner
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·J G HermanW M Linehan

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Citations

Jul 29, 1998·Journal of Internal Medicine·W G KaelinM Ohh
Aug 31, 2018·Journal of Cellular Biochemistry·Zahra FazeliMir Davood Omrani
Mar 1, 2006·International Journal of Cancer. Journal International Du Cancer·Jasmien HoebeeckFrank Speleman
Mar 8, 2011·The Journal of Pathology·Hester HappéDorien J M Peters
Jun 21, 2001·Brain Pathology·J M Alexander
Sep 7, 2007·Journal of Neuropathology and Experimental Neurology·Sebsebe LemetaKirsti Husgafvel-Pursiainen
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·William G Kaelin
Oct 22, 2003·Journal of the American Society of Nephrology : JASN·William G Kaelin

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