Abstract
Experimental evidence suggests that cardiopulmonary bypass (CPB) associated inflammatory response leads to endothelial injury and increased permeability, but this has been difficult to show clinically. We have investigated the use of von Willebrand factor (vWF), and urinary albumin excretion, as measured by the urinary albumin creatinine ratio (ACR), to demonstrate this. A total of 23 patients undergoing elective coronary artery bypass grafting were studied. Complement fragment C3a, leukotrienne B4 (LTB4), interleukin 6 (IL6), neutrophil elastase, vWF and ACR were measured on anaesthetic induction (baseline), 20 min after starting CPB, 5 min after cross-clamp removal, 5 min, 2, 6 and 24 h after termination of CPB. Anaesthetic, CPB and myocardial protection techniques were standardised. ANOVA was performed by using the distribution free Friedman test for each measured parameter. When significance differences were found (P < 0.05), post hoc analysis with Wilcoxon signed rank test was used for comparison of each time point with the base line level and differences were only accepted as significant following the Bonferroni correction (P < 0.008). Summary measures of peak versus peak and area under the cure were also analysed for ACR...Continue Reading
References
Jun 28, 1975·Lancet·B BoneuR Bierme
Aug 8, 1992·Lancet·C D StehouwerG J den Ottolander
May 1, 1991·Mayo Clinic Proceedings·D Ginsburg
Apr 1, 1991·European Heart Journal·P GoslingJ P Fox
Jan 27, 1990·BMJ : British Medical Journal·J N MatthewsP Royston
Jul 1, 1990·Annals of Clinical Biochemistry·D J RoweG F Watts
Dec 1, 1990·European Journal of Vascular Surgery·N C HickeyM H Simms
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·L De MarcoZ M Ruggeri
Jan 1, 1987·Rheumatology International·J J BelchR D Sturrock
Jan 1, 1988·Annals of Clinical Biochemistry·P GoslingA F Jones
Sep 1, 1981·The Journal of Pharmacy and Pharmacology·S A Rae, M J Smith
Sep 1, 1982·British Journal of Haematology·J C GiddingsA L Bloom
Jan 1, 1995·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·D R HoldrightP Collins
May 1, 1994·Anesthesia and Analgesia·P C Ip-YamP A Innes
Jan 1, 1994·Thrombosis Research·G ValenJ Vaage
Jan 1, 1994·Annals of Vascular Surgery·F C SmithC P Shearman
Jan 1, 1993·Heart and Vessels·K HashimotoH Kurosawa
Mar 1, 1993·American Journal of Hematology·H KagawaK Yasunaga
Apr 1, 1993·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F A Burrows, B Bissonnette
May 1, 1993·Respiratory Medicine·J ButlerG M Rocker
Citations
Jun 1, 2000·Heart and Vessels·M T ColladosL F Montaño
Feb 13, 2001·The American Journal of Cardiology·M MorelosA Biagini
Aug 8, 2001·International Journal of Cardiology·K J Millar, M South
Oct 6, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Anthony J BastinMark J Griffiths
Aug 12, 2014·Advances in Medical Sciences·Anna LisowskaWlodzimierz Jerzy Musial
Jan 21, 2016·British Journal of Anaesthesia·N J KoningC Boer
Nov 10, 2012·Burns : Journal of the International Society for Burn Injuries·Sherif S EmaraMohamed M Farag
Apr 27, 2010·Heart, Lung & Circulation·Michael P VallelyLen Kritharides
Dec 17, 2008·Heart, Lung & Circulation·Michael P VallelyLen Kritharides
Oct 6, 1999·The Annals of Thoracic Surgery·G AsimakopoulosK M Taylor
Oct 14, 2014·Journal of Critical Care·Asmat H DinPeter Dziewulski
Nov 2, 2014·PloS One·Anne Burke-GaffneyTimothy W Evans
Aug 19, 2007·Burns : Journal of the International Society for Burn Injuries·E VlachouN S Moiemen
Aug 4, 2006·Burns : Journal of the International Society for Burn Injuries·E VlachouN S Moiemen
Apr 18, 2002·Vascular Medicine·R PedrinelliM Mariani
Jun 16, 2006·Critical Care Medicine·Peter GoslingMav Manji
Aug 24, 1999·Perfusion·G Asimakopoulos