von Willebrand Factor Propeptide: A Potential Disease Biomarker Not Affected by ABO Blood Groups

Biomarker Insights
Mahat MarianorCh Che Maraina

Abstract

Epidemiological studies have shown that vascular-related disorders are associated with high von Willebrand factor antigen (VWF:Ag) and VWF propeptide (VWFpp). VWFpp is secreted together with VWF:Ag upon endothelial cell activation, hence it could be a potential biomarker. This study was conducted to compare between VWF:Ag and VWFpp levels among 30 healthy individuals and 42 patients with high levels of VWF:Ag in different medical conditions and ABO blood groups. VWFpp levels were strongly correlated with VWF:Ag. VWF:Ag and VWFpp levels were significantly increased in patients compared to healthy individuals. VWFpp is not affected by ABO blood group in both healthy individual and patient groups unlike VWF:Ag. As expected, this study showed that VWFpp levels increased in parallel with VWF:Ag levels in patients with diseases associated with endothelial activation. VWFpp though nonspecific is a potential biomarker reflecting underlying pathophysiological changes in various medical conditions with an additional advantage of not being influenced by ABO blood groups.

References

Mar 29, 2006·Annals of Hematology·Massimo Franchini, Giuseppe Lippi
Dec 4, 2008·Thrombosis Research·Armin J Reininger
Mar 30, 2010·Journal of Thrombosis and Haemostasis : JTH·M C van SchieM J Hollestelle
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May 16, 2014·Blood Reviews·Michelle A H SonneveldFrank W G Leebeek

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Citations

Jan 23, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Bin YanYiming Zhao

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Methods Mentioned

BETA
Assay
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

SPSS

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