PMID: 8440408Feb 1, 1993Paper

von Willebrand factor

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Z M Ruggeri, J Ware

Abstract

von Willebrand factor is a multimeric glycoprotein essential for the normal arrest of bleeding after tissue injury (hemostasis). The molecule is present in blood, both in plasma and inside platelets, as well as in endothelial cells and the subendothelial matrix of the vessel wall. Through multiple functional domains, von Willebrand factor mediates the attachment of platelets to exposed tissues, where discontinuity of the vascular endothelium occurs, and the subsequent platelet aggregation leading to the formation of platelet thrombi. The crucial role of von Willebrand factor in platelet function is particularly apparent when hemodynamic conditions create blood flow with high shear stress, as in capillaries under physiologic conditions or in stenosed and partially occluded arteries in disease states. The involvement of von Willebrand factor in the processes that lead to acute thrombosis has attracted considerable interest on the molecular and functional biology of the protein. Indeed, understanding the mechanisms and structural bases for von Willebrand factor function may result in new and effective approaches to anti-thrombotic intervention.

Citations

Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J C GiddingsM J Lewis
Feb 24, 1999·Haemophilia : the Official Journal of the World Federation of Hemophilia·A C ChangM J Weinstein
Jul 9, 2002·Microbiology·Joakim BjerketorpLars Frykberg
Oct 30, 2007·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hiroyuki Yokota
Mar 19, 2008·Circulation·Alexander O SpielBernd Jilma
Dec 10, 2009·Korean Circulation Journal·Boris Leithäuser, Jai-Wun Park
Nov 27, 2010·Expert Review of Cardiovascular Therapy·Christa FirbasBernd Jilma
May 6, 2011·Archives of Virology·Fanyu LinFeng Yang
Jan 10, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·Q ShiR R Montgomery
May 10, 2012·Journal of Thrombosis and Haemostasis : JTH·J E van LoonM P M de Maat
Jan 23, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Marcus StockschlaederUlrich Budde
May 21, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Gonul BuyukyilmazYildiz Dallar
Feb 14, 2014·Expert Review of Hematology·Sameh MikhailAmer Zeidan
Oct 22, 2015·European Journal of Human Genetics : EJHG·Janine van LoonChristopher O'Donnell
Jun 6, 2018·Journal of Bacteriology·T Jarrod SmithGeorge A O'Toole
Jul 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yathreb AsaadNetanel Korin
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·G R De MeyerH Bult
Mar 8, 1996·The Journal of Biological Chemistry·B Felding-HabermannZ M Ruggeri
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·I ZacharyJ Martin
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Keith R MilnerAlan J Snyder
Oct 7, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kolja EppertIrene L Andrulis
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·A A GarciaP H Reitsma
Nov 22, 2008·Journal of Cellular Physiology·Irina A PotapovaSergey V Doronin
Nov 18, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Md Imtaiyaz HassanFaizan Ahmad
Mar 13, 2012·Biotechnology Journal·Birgit K SeyfriedGünter Allmaier
Jun 9, 2010·Journal of Mass Spectrometry : JMS·Birgit K SeyfriedGünter Allmaier
Dec 17, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Dongyi ZhangZhengwen Zhang
Apr 16, 2011·Pflügers Archiv : European journal of physiology·Miroslaw RybaltowskiTetsumei Urano
Jan 1, 1998·Hematology·P M Mannucci
Nov 1, 2016·Journal of Biomedical Materials Research. Part a·Hassan RammalHalima Kerdjoudj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.