Voriconazole: Poor Oral Bioavailability and Possible Renal Toxicity in an Infant With Invasive Aspergillosis

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
Jenny A WalldorfAllison B Lardieri

Abstract

Voriconazole is the recommended agent of choice for treatment of invasive aspergillosis; however, achieving therapeutic serum concentrations while avoiding toxicity, both with intravenous and oral formulations, is challenging in infants. We report the case of an infant with confirmed invasive aspergillosis who developed renal toxicity possibly associated with IV voriconazole. Renal function improved upon withdrawal of the IV agent and switch to the oral formulation. The infant subsequently required large oral weight-based dosing to achieve therapeutic voriconazole serum concentrations. This case illustrates a rare side effect associated with voriconazole as well as the issues surrounding the pharmacokinetic profile of voriconazole in a pediatric patient.

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Nov 18, 2003·British Journal of Clinical Pharmacology·Lynn PurkinsDon Nichols
Jan 4, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andres PascualOscar Marchetti
Dec 17, 2008·Antimicrobial Agents and Chemotherapy·Mats O KarlssonPeter A Milligan
Oct 23, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S MiyakisD Marriott
Dec 3, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael NeelyJill Hoffman
Jul 28, 2010·Antimicrobial Agents and Chemotherapy·Thomas J WalshIrja Lutsar
Jul 20, 2011·Antimicrobial Agents and Chemotherapy·Peter F TrokeWilliam W Hope
Dec 23, 2011·The Journal of Antimicrobial Chemotherapy·Pere Soler-PalacínConcepció Figueras
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Lena E FribergPing Liu
Mar 28, 2012·Antimicrobial Agents and Chemotherapy·A M L Oude LashofB J Kullberg
Jul 4, 2012·Antimicrobial Agents and Chemotherapy·Michael J DoltonAndrew J McLachlan
Jul 5, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Wan Beom ParkKyung-Sang Yu
Nov 2, 2012·Antimicrobial Agents and Chemotherapy·Imke H BartelinkMarc Bierings
Jan 17, 2013·BMC Infectious Diseases·Craig M LillyDavid R Luke
Mar 25, 2016·The Journal of Antimicrobial Chemotherapy·Alison BoastAmanda Gwee

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Related Papers

The Pediatric Infectious Disease Journal
William J Steinbach
Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
V Ignatyeva, M Avxentyeva
© 2022 Meta ULC. All rights reserved