Vortex-assisted emulsification semimicroextraction for the analytical control of restricted ingredients in cosmetic products: determination of bronopol by liquid chromatography

Analytical and Bioanalytical Chemistry
Pablo MirallesAmparo Salvador

Abstract

Vortex-assisted emulsification semimicroextraction is proposed as a one-step solution-extraction procedure for sample preparation in cosmetic products. The procedure allows rapid preparation based on dispersion of the sample in a mixture of 1 mL of n-hexane and 0.5 mL of ethanol, followed by the addition of 0.5 mL of water and centrifugation to obtain two separated phases. This procedure provides good sample clean-up with minimum dilution and is very useful for the determination of ingredients with restricted concentrations, such as bronopol. The procedure was applied to the determination of bronopol by liquid chromatography with UV detection. The best chromatographic separation was obtained by using a C18 column set at 40 °C and performing a stepwise elution with a mixture of ethanol/aqueous 1 % acetic acid solution as mobile phase pumped at 0.5 mL min(-1). The detection wavelength was set at 250 nm and the total run time required was 12 min. The method was successfully applied to 18 commercial cosmetic samples including creams, shampoos, and bath gels. Good recoveries and repeatability were obtained, with a limit of detection of 0.9 μg mL(-1), which makes the method suitable for the analytical control of cosmetic products. Mo...Continue Reading

References

Nov 1, 1988·Antimicrobial Agents and Chemotherapy·J A ShepherdP Gilbert
Jun 14, 2002·Journal of Pharmaceutical and Biomedical Analysis·Huafu WangKeith Helliwell
Aug 10, 2010·Journal of Chromatography. a·Chunhong JiaPingzhong Yu
Aug 26, 2011·Environmental Science & Technology·Lokesh P PadhyeChing-Hua Huang
Sep 2, 2011·Journal of Chromatography. a·Zhong-Hua YangDong-Hui Liu
May 23, 2012·International Journal of Cosmetic Science·M MatczukM Mojski
Oct 4, 2014·Journal of Pharmaceutical and Biomedical Analysis·Pablo MirallesAmparo Salvador

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Citations

Jun 18, 2019·Journal of Food Science and Technology·Amit ChilbulePriyanka Singh Rao
Feb 13, 2021·Regulatory Toxicology and Pharmacology : RTP·Lucía López-SánchezVirginia Merino
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria CeleiroMarta Lores

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