Voxel based comparison and texture analysis of 18F-FDG and 18F-FMISO PET of patients with head-and-neck cancer

PloS One
Markus KroenkeNagara Tamaki

Abstract

Hypoxia can induce radiation resistance and is an independent prognostic marker for outcome in head and neck cancer. As 18F-FMISO (FMISO), a hypoxia tracer for PET, is far less common than 18F-FDG (FDG) and two separate PET scans result in doubled cost and radiation exposure to the patient, we aimed to predict hypoxia from FDG PET with new techniques of voxel based analysis and texture analysis. Thirty-eight patients with head-and-neck cancer underwent consecutive FDG and FMISO PET scans before any treatment. ROIs enclosing the primary cancer were compared in a voxel-by-voxel manner between FDG and FMISO PET. Tumour hypoxia was defined as the volume with a tumour-to-muscle ratio (TMR) > 1.25 in the FMISO PET and hypermetabolic volume was defined as >50% SUVmax in the FDG PET. The concordance rate was defined as percentage of voxels within the tumour which were both hypermetabolic and hypoxic. 38 different texture analysis (TA) parameters were computed based on the ROIs and correlated with presence of hypoxia. Within the hypoxic tumour regions, the FDG uptake was twice as high as in the non-hypoxic tumour regions (SUVmean 10.9 vs. 5.4; p<0.001). A moderate correlation between FDG and FMISO uptake was found by a voxel-by-voxel co...Continue Reading

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Citations

Apr 23, 2020·Radiation Oncology·M UnterrainerC Belka
Dec 11, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Sho FuruyaNagara Tamaki
Mar 7, 2021·Diagnostics·Manuel Piñeiro-FielPablo Aguiar
Mar 30, 2021·Journal of Healthcare Engineering·Eali Stephen Neal JoshuaYung-Cheol Byun

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Methods Mentioned

BETA
xenograft

Software Mentioned

FMISO
GLZSM
TrueX
SPSS
IntelliSpace Portal
NGLDM
R
Excel

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