Voxel-based comparison of [68 Ga]Ga-RM2-PET/CT and [68 Ga]Ga-PSMA-11-PET/CT with histopathology for diagnosis of primary prostate cancer

EJNMMI Research
Thomas Franz FassbenderMichael Mix

Abstract

Focal therapies or focally escalated therapies of primary prostate cancer are becoming more and more important. This increases the need to identify the exact extension of the intraprostatic tumor and possible dominant intraprostatic lesions by imaging techniques. While the prostate-specific membrane antigen (PSMA) is already a well-established target for imaging of prostate cancer cells, the gastrin-releasing peptide receptor (GRPR) seems to provide interesting additional information. Histopathology was used to examine the extent to which the single and combined image information of PET scans targeting GRPR and PSMA might lead to better tumor delineation. Eight patients with histologically proven primary prostate cancer underwent two positron emission tomography with computer tomography scans, [68Ga]Ga-RM2-PET/CT (RM2-PET) and [68Ga]Ga-PSMA-11-PET/CT (PSMA-PET), prior to radical prostatectomy. RM2-PET data were correlated voxel-wise to a voxel-based model of the histopathologic tumor volume information. The results were compared to, correlated to, and combined with the correlation of PSMA-PET data analyzed analogously. In 4/8 patients, RM2-PET showed a higher signal in histologically proven tumor regions compared to PSMA. There...Continue Reading

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Citations

Jun 27, 2021·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·F LuciaU Schick
Aug 15, 2021·European Journal of Radiology·Farshad MoradiAndrei Iagaru

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