Voxel-based morphometry analysis of double inversion-recovery magnetic resonance imaging for detecting microscopic lesions: a simulation study

Radiological Physics and Technology
Sato YusukeTsushima Yoshito

Abstract

Double inversion-recovery (DIR) imaging has the potential to improve the detection of subcortical lesions through the use of voxel-based morphometry (VBM) analysis. The aim of this study was to clarify the characteristics of detectable lesions by performing a VBM analysis on DIR images of simulated lesions. Twenty healthy volunteers underwent magnetic resonance imaging using a head three-dimensional DIR sequence. The images were processed using SPM12; then, the selected images with simulated lesions were analyzed via VBM. The VBM results were evaluated using free-response receiver-operating characteristic curves and a receiver-operating characteristic analysis. The sensitivity was 100% (5/5), with 5.6 false-positive objects per case, in simulated lesions with a contrast of 0.6 and a size of 2.4 mm. The sensitivity was 80% (4/5), with 5.4 false-positive objects per case, in simulated lesions with a contrast of 0.5 and a size of 2.4 mm. The mean area under the curve value was increased from 0.783 to 0.883 using VBM, with a statistically significant difference (p < 0.01). The VBM analysis of the DIR images using SPM alone showed the potential to detect subcortical microscopic lesions. Early detection of Alzheimer's disease may be ...Continue Reading

References

Jun 2, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P A BoulbyG J Barker
May 7, 2011·European Journal of Radiology·Zhiye ChenLin Ma
Jan 12, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manon BrundelGeert Jan Biessels
May 23, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Yuichiro IiHidekazu Tomimoto
Nov 13, 2013·Physics in Medicine and Biology·Lothar SpiesAlaleh Raji
Dec 4, 2014·Stroke; a Journal of Cerebral Circulation·Jan Willem van DalenEdo Richard

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