Voxel-based morphometry at ultra-high fields. a comparison of 7T and 3T MRI data

NeuroImage
Rene SeigerRupert Lanzenberger

Abstract

Recent technological progress enables MRI recordings at ultra-high fields of 7 T and above leading to brain images of higher resolution and increased signal-to-noise ratio. Despite these benefits, imaging at 7 T exhibits distinct challenges due to B1 field inhomogeneities, causing decreased image quality and problems in data analysis. Although several strategies have been proposed, a systematic investigation of bias-corrected 7 T data for voxel-based morphometry (VBM) is still missing and it is an ongoing matter of debate if VBM at 7 T can be carried out properly. Here, an optimized VBM study was conducted, evaluating the impact of field strength (3T vs. 7 T) and pulse sequence (MPRAGE vs. MP2RAGE) on gray matter volume (GMV) estimates. More specifically, twenty-two participants were measured under the conditions 3T MPRAGE, 7 T MPRAGE and 7 T MP2RAGE. Due to the fact that 7 T MPRAGE data exhibited strong intensity inhomogeneities, an alternative preprocessing pipeline was proposed and applied for that data. VBM analysis revealed higher GMV estimates for 7 T predominantly in superior cortical areas, caudate nucleus, cingulate cortex and the hippocampus. On the other hand, 3T yielded higher estimates especially in inferior cortic...Continue Reading

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Citations

Jun 3, 2015·Journal of Magnetic Resonance Imaging : JMRI·Gosuke OkuboKaori Togashi
Feb 24, 2016·Current Opinion in Neurology·Irene Wang, Andreas Alexopoulos
Sep 1, 2015·NeuroImage·Christine Lucas TardifPierre-Louis Bazin
Feb 9, 2017·Medical Physics·Khosro BahramiDinggang Shen
May 17, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Rene SeigerRupert Lanzenberger
Apr 22, 2016·Magma·Maximilian N VoelkerOliver Speck
Jun 9, 2019·The International Journal of Neuropsychopharmacology·Christoph KrausRupert Lanzenberger
Apr 22, 2018·Current Treatment Options in Neurology·Tim SinneckerRegina Schlaeger
Jan 9, 2019·Frontiers in Aging Neuroscience·Alexander KautzkyRupert Lanzenberger
Oct 4, 2018·Current Neurology and Neuroscience Reports·Jing YangDavid E Vaillancourt
Aug 26, 2019·Magnetic Resonance Imaging·Ruoyun MaPierre-François Van de Moortele
May 12, 2021·Journal of Magnetic Resonance Imaging : JMRI·Refaat E Gabr
Jul 16, 2021·NeuroImage·Ícaro A F OliveiraWietske van der Zwaag

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