Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder

NeuroImage. Clinical
Janna Marie Bas-HoogendamNic J A van der Wee

Abstract

Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric co-morbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in gray matter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multi-site imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples. An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-participants (n = 213) using voxel-based morphometry. A hypothesis-driven region of interest (ROI) approach was used, focusing on the basal ganglia, the amygdala-hippocampal complex, the prefrontal cortex, and the parietal cortex. SAD-patients had larger GM volume in the dorsal striatum when compared to HC-participants. This increase correlated positively with the severity of self-reported social anxiety symptoms. No SAD-related differences in GM v...Continue Reading

Citations

Jul 4, 2020·Human Brain Mapping·Janna Marie Bas-HoogendamUNKNOWN ENIGMA-Anxiety Working Group
Apr 28, 2018·International Journal of Methods in Psychiatric Research·Janna Marie Bas-HoogendamP Michiel Westenberg
Jun 23, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonia N KaczkurkinTheodore D Satterthwaite
Apr 23, 2020·Frontiers in Neuroscience·Marek KijonkaBarbara Bobek-Billewicz
Apr 10, 2020·F1000Research·Janna Marie Bas-Hoogendam, P Michiel Westenberg
Mar 2, 2021·Frontiers in Neuroscience·Linda TsanScott E Kanoski
Jul 23, 2021·Translational Psychiatry·Laura K M HanBrenda W J H Penninx

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