Abstract
Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric co-morbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in gray matter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multi-site imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples. An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-participants (n = 213) using voxel-based morphometry. A hypothesis-driven region of interest (ROI) approach was used, focusing on the basal ganglia, the amygdala-hippocampal complex, the prefrontal cortex, and the parietal cortex. SAD-patients had larger GM volume in the dorsal striatum when compared to HC-participants. This increase correlated positively with the severity of self-reported social anxiety symptoms. No SAD-related differences in GM v...Continue Reading
Citations
Jun 13, 2020·Journal of Neuroscience Research·Sarah NooraniRajesh Kumar
Jul 4, 2020·Human Brain Mapping·Janna Marie Bas-HoogendamUNKNOWN ENIGMA-Anxiety Working Group
Oct 5, 2020·European Child & Adolescent Psychiatry·Song WangQiyong Gong
Oct 10, 2018·Frontiers in Psychiatry·Xiuli WangSong Wang
Apr 28, 2018·International Journal of Methods in Psychiatric Research·Janna Marie Bas-HoogendamP Michiel Westenberg
Feb 7, 2019·Frontiers in Psychiatry·Janna Marie Bas-Hoogendam
Dec 12, 2019·Molecular Psychiatry·Olof R HjorthTomas Furmark
Jun 23, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Antonia N KaczkurkinTheodore D Satterthwaite
Mar 22, 2020·Translational Psychiatry·Paul M ThompsonUNKNOWN ENIGMA Consortium
Apr 23, 2020·Frontiers in Neuroscience·Marek KijonkaBarbara Bobek-Billewicz
Apr 10, 2020·F1000Research·Janna Marie Bas-Hoogendam, P Michiel Westenberg
Nov 28, 2020·Journal of Affective Disorders·Xiuli WangDi Kong
Jul 21, 2020·Brain, Behavior, and Immunity·Yuan-Yuan HanCheng Long
Mar 2, 2021·Frontiers in Neuroscience·Linda TsanScott E Kanoski
Mar 19, 2021·NeuroImage. Clinical·Natania A CraneHeide Klumpp
Jun 24, 2021·EBioMedicine·Janna Marie Bas-HoogendamNic J A van der Wee
Jul 23, 2021·Translational Psychiatry·Laura K M HanBrenda W J H Penninx
Aug 28, 2021·Journal of Clinical Medicine·Yolanda Álvarez-PérezWenceslao Peñate
Aug 24, 2021·General Psychiatry·Shuqi XieZhi Yang
Oct 14, 2020·Brain Imaging and Behavior·Running NiuPeng Zhou
Jan 23, 2022·Translational Psychiatry·Xun ZhangQiyong Gong