Voxel-based morphometry results in first-episode schizophrenia: a comparison of publicly available software packages.

Brain Imaging and Behavior
Chen LiHong Yin

Abstract

Investigations of brain structure in schizophrenia using magnetic resonance imaging (MRI) have identified variations in regional grey matter (GM) volume throughout the brain but the results are mixed. This study aims to investigate whether the inconsistent voxel-based morphometry (VBM) findings in schizophrenia are due to the use of different software packages. T1 MRI images were obtained from 86 first-episode schizophrenia (FESZ) patients and 86 age- and gender-matched Healthy controls (HCs). VBM analysis was carried out using FMRIB software library (FSL) 5.0 and statistical parametric mapping 8 (SPM8). All images were processed using the default parameter settings as provided by these software packages. FSL-VBM revealed widespread GM volume reductions in FESZ patients compared with HCs, however, for SPM-VBM, only increased and circumscribed GM volume changes were found, both software revealed increased GM volume within cerebellum. Significant correlations between Positive and Negative Syndrome Scale (PANSS) and GM volume were mainly found in frontal regions. Algorithms of GM tissue segmentation, image registration and statistical strategies might contribute to these disparate results.

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Feb 13, 2001·Biological Psychiatry·T IchimiyaY Sudo
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Dec 31, 2002·The American Journal of Psychiatry·Kiyoto KasaiRobert W McCarley
Jun 3, 2005·Brain : a Journal of Neurology·Michio SuzukiMasayoshi Kurachi
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Dec 7, 2005·The American Journal of Psychiatry·Robyn HoneaClare E Mackay
Nov 14, 2006·Schizophrenia Research·Adegboyega SaparaVeena Kumari
Aug 19, 2007·Brain : a Journal of Neurology·Gwenaëlle DouaudAnthony James
Sep 1, 2007·NeuroImage·John Ashburner
Apr 3, 2008·The American Journal of Psychiatry·Ian Ellison-WrightEd Bullmore
Dec 19, 2009·European Archives of Psychiatry and Clinical Neuroscience·Motomu SugaKiyoto Kasai
Feb 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Michael P HarmsJohn G Csernansky
Nov 19, 2010·Schizophrenia Bulletin·Philip R SzeszkoDelbert G Robinson
Sep 7, 2011·Archives of General Psychiatry·Neeltje E M van HarenRené S Kahn
Jan 17, 2012·Neuroscience and Biobehavioral Reviews·Alana M ShepherdMelissa J Green
Jul 15, 2015·The Cerebellum·Omar MothersillGary Donohoe
Aug 8, 2015·The Cochrane Database of Systematic Reviews·Lena PalaniyappanKarla Soares-Weiser
Feb 5, 2016·Brain Imaging and Behavior·Yanzhi BiJie Tian
Jul 3, 2016·Schizophrenia Bulletin·Letícia Sanguinetti CzepielewskiDeanna M Barch
May 2, 2018·Radiology·Loredana StorelliUNKNOWN MAGNIMS Study Group

❮ Previous
Next ❯

Citations

Feb 9, 2021·Journal of Sleep Research·LiQin ShengPingLei Pan

❮ Previous
Next ❯

Software Mentioned

FSL Automated Segmentation Tool ( FAST )
SnPM
brain extracting tool BET
fsl
VBM
Matlab
Statistical Parametric Mapping
New Segment for SPM Anatomical Registration Through Exponentia...
FMRIB Software Library
CARET

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.