Voxel size and gray level normalization of CT radiomic features in lung cancer

Scientific Reports
Muhammad Shafiq-Ul-HassanEduardo Gerardo Moros

Abstract

Radiomic features are potential imaging biomarkers for therapy response assessment in oncology. However, the robustness of features with respect to imaging parameters is not well established. Previously identified potential imaging biomarkers were found to be intrinsically dependent on voxel size and number of gray levels (GLs) in a recent texture phantom investigation. Here, we validate the voxel size and GL in-phantom normalizations in lung tumors. Eighteen patients with non-small cell lung cancer of varying tumor volumes were analyzed. To compare with patient data, phantom scans were acquired on eight different scanners. Twenty four previously identified features were extracted from lung tumors. The Spearman rank (rs) and interclass correlation coefficient (ICC) were used as metrics. Eight out of 10 features showed high (rs > 0.9) and low (rs < 0.5) correlations with number of voxels before and after normalizations, respectively. Likewise, texture features were unstable (ICC < 0.6) and highly stable (ICC > 0.8) before and after GL normalizations, respectively. We conclude that voxel size and GL normalizations derived from a texture phantom study also apply to lung tumors. This study highlights the importance and utility of i...Continue Reading

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Citations

Aug 22, 2020·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Rodrigo DelgadilloRadka Stoyanova
Mar 20, 2019·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Pamela SungBalaji Ganeshan
May 14, 2019·Expert Review of Precision Medicine and Drug Development·Vishwa S Parekh, Michael A Jacobs
Mar 15, 2019·Scientific Reports·Elaine Johanna LimkinCharlotte Robert
Jul 6, 2019·Scientific Reports·Philip WhybraEmiliano Spezi
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Jul 21, 2020·Physics in Medicine and Biology·R Da-AnoM Hatt
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Jan 8, 2021·Medical & Biological Engineering & Computing·Panagiotis MarentakisConstantinos Loukas
Feb 4, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Shin-Hyung ParkJae-Chul Kim
Mar 5, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Isabella CastiglioniFrancesco Sardanelli
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Mar 16, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Matteo TamponiMaurizio Conti
May 4, 2021·Computers in Biology and Medicine·Sepideh AmiriSusan Cheraghi
May 18, 2021·The Journal of Clinical Endocrinology and Metabolism·Caroline ZaworskiEmily M Stein
Feb 4, 2021·Aging and Disease·Qian ChenYunjun Yang
Jan 13, 2021·Cold Spring Harbor Perspectives in Medicine·Ilke TunaliMatthew B Schabath

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Methods Mentioned

BETA
feature extraction

Software Mentioned

RLNU
NGTDM
GLRLM
GLSZM
GLNU
SPSS

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