Voxel size dependency, reproducibility and sensitivity of an in vivo bone loading estimation algorithm

Journal of the Royal Society, Interface
Patrik ChristenR Müller

Abstract

A bone loading estimation algorithm was previously developed that provides in vivo loading conditions required for in vivo bone remodelling simulations. The algorithm derives a bone's loading history from its microstructure as assessed by high-resolution (HR) computed tomography (CT). This reverse engineering approach showed accurate and realistic results based on micro-CT and HR-peripheral quantitative CT images. However, its voxel size dependency, reproducibility and sensitivity still need to be investigated, which is the purpose of this study. Voxel size dependency was tested on cadaveric distal radii with micro-CT images scanned at 25 µm and downscaled to 50, 61, 75, 82, 100, 125 and 150 µm. Reproducibility was calculated with repeated in vitro as well as in vivo HR-pQCT measurements at 82 µm. Sensitivity was defined using HR-pQCT images from women with fracture versus non-fracture, and low versus high bone volume fraction, expecting similar and different loading histories, respectively. Our results indicate that the algorithm is voxel size independent within an average (maximum) error of 8.2% (32.9%) at 61 µm, but that the dependency increases considerably at voxel sizes bigger than 82 µm. In vitro and in vivo reproducibil...Continue Reading

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Citations

Nov 10, 2016·Journal of the Mechanical Behavior of Biomedical Materials·Clara SandinoSteven K Boyd
Apr 22, 2017·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Sandro D BadilattiRalph Müller
Jun 24, 2017·Current Osteoporosis Reports·Patrik Christen, Ralph Müller
May 17, 2018·Personalized Medicine·Patrik Christen
Jul 20, 2017·Journal of Materials Science. Materials in Medicine·Ibrahim Fatih CengizRui L Reis
Nov 11, 2018·Biomechanics and Modeling in Mechanobiology·Alexander SynekDieter H Pahr
Jun 8, 2018·Biomechanics and Modeling in Mechanobiology·Paul F EganStephen J Ferguson
Jan 1, 2018·Biomechanics and Modeling in Mechanobiology·Alexander Synek, Dieter H Pahr
May 5, 2021·Journal of Anatomy·Emma E BirdMatthew M Skinner
Jul 13, 2021·Frontiers in Bioengineering and Biotechnology·Matthias WalleCaitlyn J Collins

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