Voxel-wise correlations between cognition and cerebral blood flow using arterial spin-labeled perfusion MRI in patients with Alzheimer's disease: a cross-sectional study

BMC Neurology
Tomohiro KanetaTomio Inoue

Abstract

To analyze voxel-wise correlation between cerebral blood flow (CBF) measured using ASL-MRI and cognition in patients with Alzheimer's disease (AD). Forty-one patients diagnosed with AD or mild cognitive impairment due to AD were recruited for this study. CBF images were obtained using ASL-MRI (n = 41) with a post-labeling delay (PLD) of 1.5 and 2.5 s (PLD1.5 and PLD2.5, respectively) using a 3 T scanner, in addition to brain perfusion SPECT with N-isopropyl-4-[I-123]iodoamphetamine (n = 28). Voxel-based analyses were performed for ASL-MRI and SPECT using Mini-Mental State Examination (MMSE) scores as covariates. Differences in CBF between PLD1.5 and PLD2.5 were assessed using a paired t-test with SPM12. Significant positive correlations were observed between MMSE scores and CBF at PLD1.5 in the right posterior cingulate cortex (PCC), and both temporo-parietal association cortexes. At PLD2.5, significant positive correlations were determined for MMSE scores and CBF in the superior parietal lobule and the right temporo-parietal association cortex. SPECT showed significant positive correlations in the PCC and both temporo-parietal association cortexes (right-side dominant). PLD1.5 showed significantly higher CBF than PLD2.5 in the...Continue Reading

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Citations

Oct 16, 2018·Journal of Magnetic Resonance Imaging : JMRI·Shaozhen YanJie Lu
Aug 14, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Julie OttoySteven Staelens
Jan 18, 2020·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Satoshi TsuchiyaHiroaki Shimokawa
Jan 22, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Jenny CeccariniKoen Van Laere
Jun 27, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Elizabeth Frances McKiernanJohn O'Brien
Jun 10, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Rui WangOzioma C Okonkwo

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Software Mentioned

SPM
SPM12
PLD
GradWarp
Statistical mapping ( SPM12

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