Voxel-wise detection of functional networks in white matter

NeuroImage
Yali HuangZhaohua Ding

Abstract

Functional magnetic resonance imaging (fMRI) depicts neural activity in the brain indirectly by measuring blood oxygenation level dependent (BOLD) signals. The majority of fMRI studies have focused on detecting cortical activity in gray matter (GM), but whether functional BOLD signal changes also arise in white matter (WM), and whether neural activities trigger hemodynamic changes in WM similarly to GM, remain controversial, particularly in light of the much lower vascular density in WM. However, BOLD effects in WM are readily detected under hypercapnic challenges, and the number of reports supporting reliable detections of stimulus-induced activations in WM continues to grow. Rather than assume a particular hemodynamic response function, we used a voxel-by-voxel analysis of frequency spectra in WM to detect WM activations under visual stimulation, whose locations were validated with fiber tractography using diffusion tensor imaging (DTI). We demonstrate that specific WM regions are robustly activated in response to visual stimulation, and that regional distributions of WM activation are consistent with fiber pathways reconstructed using DTI. We further examined the variation in the concordance between WM activation and fiber d...Continue Reading

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Citations

Jul 6, 2019·Human Brain Mapping·Jiao LiWei Liao
Apr 19, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H LinY Han
Feb 20, 2019·Frontiers in Psychology·Wenfu LiJiang Qiu
Oct 22, 2019·Frontiers in Neurology·Péter FaragóZsigmond Tamás Kincses
Oct 20, 2020·Cerebral Cortex Communications·Ting WangZhaohua Ding
Nov 20, 2020·Brain : a Journal of Neurology·Alessandro SalvalaggioMaurizio Corbetta
May 4, 2021·Frontiers in Human Neuroscience·Qiang XuRongfeng Qi
Apr 25, 2020·NeuroImage·Arabinda MishraJohn C Gore
Oct 31, 2021·Proceedings of the National Academy of Sciences of the United States of America·Muwei LiJohn C Gore

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