Voxel-wise motion artifacts in population-level whole-brain connectivity analysis of resting-state FMRI

PloS One
Tamás SpisákMiklós Emri

Abstract

Functional Magnetic Resonance Imaging (fMRI) based brain connectivity analysis maps the functional networks of the brain by estimating the degree of synchronous neuronal activity between brain regions. Recent studies have demonstrated that "resting-state" fMRI-based brain connectivity conclusions may be erroneous when motion artifacts have a differential effect on fMRI BOLD signals for between group comparisons. A potential explanation could be that in-scanner displacement, due to rotational components, is not spatially constant in the whole brain. However, this localized nature of motion artifacts is poorly understood and is rarely considered in brain connectivity studies. In this study, we initially demonstrate the local correspondence between head displacement and the changes in the resting-state fMRI BOLD signal. Than, we investigate how connectivity strength is affected by the population-level variation in the spatial pattern of regional displacement. We introduce Regional Displacement Interaction (RDI), a new covariate parameter set for second-level connectivity analysis and demonstrate its effectiveness in reducing motion related confounds in comparisons of groups with different voxel-vise displacement pattern and prepro...Continue Reading

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Citations

Dec 25, 2015·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Masami GotoTohoru Takeda
Nov 29, 2015·Seminars in Ultrasound, CT, and MR·András JakabDaniela Prayer
Jul 15, 2015·Pain·Vanda FariaDavid Borsook
Nov 20, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Csaba AranyiMiklós Emri
Jun 17, 2016·Cephalalgia : an International Journal of Headache·Catherine D ChongTodd J Schwedt
Nov 2, 2017·Human Brain Mapping·Theodore D SatterthwaiteDaniel H Wolf
Jan 12, 2020·Nature Communications·Tamas SpisakUlrike Bingel

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Software Mentioned

FLIRT
visreg
NOREG
m3i
GSREG
FSL McFlirt
glm
FNIRT
fdrtool
R

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