Voxelized Model of Brain Infusion That Accounts for Small Feature Fissures: Comparison With Magnetic Resonance Tracer Studies

Journal of Biomechanical Engineering
Wei DaiMalisa Sarntinoranont

Abstract

Convection enhanced delivery (CED) is a promising novel technology to treat neural diseases, as it can transport macromolecular therapeutic agents greater distances through tissue by direct infusion. To minimize off-target delivery, our group has developed 3D computational transport models to predict infusion flow fields and tracer distributions based on magnetic resonance (MR) diffusion tensor imaging data sets. To improve the accuracy of our voxelized models, generalized anisotropy (GA), a scalar measure of a higher order diffusion tensor obtained from high angular resolution diffusion imaging (HARDI) was used to improve tissue segmentation within complex tissue regions of the hippocampus by capturing small feature fissures. Simulations were conducted to reveal the effect of these fissures and cerebrospinal fluid (CSF) boundaries on CED tracer diversion and mistargeting. Sensitivity analysis was also conducted to determine the effect of dorsal and ventral hippocampal infusion sites and tissue transport properties on drug delivery. Predicted CED tissue concentrations from this model are then compared with experimentally measured MR concentration profiles. This allowed for more quantitative comparison between model predictions ...Continue Reading

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Citations

Jan 26, 2018·Journal of Mathematical Biology·Eduard RohanAlena Jonášová
Jul 18, 2018·Fluids and Barriers of the CNS·Julian Rey, Malisa Sarntinoranont
Sep 22, 2018·Journal of the Mechanical Behavior of Biomedical Materials·Ruizhi Wang, Malisa Sarntinoranont
Sep 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Marco VidottoDaniele Dini

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