Voxelwise computed diffusion-weighted imaging for the detection of cytotoxic oedema in brain imaging: a pilot study

The Neuroradiology Journal
Ferdinand SeithGeorg Bier

Abstract

Aim To evaluate voxelwise computed diffusion-weighted imaging (vcDWI) for the detection of cytotoxic oedema in brain imaging and to quantify the benefit of lesion contrast in comparison to standard b = 1000 s/mm2 by the example of acute ischaemic stroke. Materials and methods A retrospective evaluation of 66 patients (63 ± 15.9 years) suspected for acute ischaemic stroke who received diffusion-weighted magnetic resonance imaging and fluid-attenuated inversion recovery sequence. A neuroradiologist evaluated all examinations for acute ischaemic stroke based on diffusion-weighted imaging, the apparent diffusion coefficient and fluid-attenuated inversion recovery (reference standard) and 6 weeks later the vcDWI in a randomised manner. Time of analysis was noted. Signal intensities were acquired in lesions, in healthy tissue as well as in the cerebrospinal fluid. Contrast ratios and coefficients of variation were computed. Results A total of 218 lesions was found in 46/66 patients. vcDWI identified all patients and lesions correctly. The median evaluation time was 36 seconds (4-126 s) for the vcDWI and 44 seconds (9-186 s; P < 0.001) for the diffusion-weighted imaging/apparent diffusion coefficient reading. The contrast ratio in vcD...Continue Reading

References

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Jun 21, 2015·Journal of Neurology·Dimitri RenardCatherine Lechiche
Jan 23, 2016·AJR. American Journal of Roentgenology·Akio OguraNatsumi Yamaguchi

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Citations

Feb 18, 2021·The British Journal of Radiology·Thomas SartorettiSabine Sartoretti-Schefer

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Software Mentioned

Imagine
SPSS
Matlab
vcDWI

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