VP1 Amino Acid Residue 145 of Enterovirus 71 Is a Key Residue for Its Receptor Attachment and Resistance to Neutralizing Antibody during Cynomolgus Monkey Infection

Journal of Virology
Ken FujiiSatoshi Koike

Abstract

Enterovirus 71 (EV71) is a causative agent of hand, foot, and mouth disease and sometimes causes severe or fatal neurological complications. The amino acid at VP1-145 determines the virological characteristics of EV71. Viruses with glutamic acid (E) at VP1-145 (VP1-145E) are virulent in neonatal mice and transgenic mice expressing human scavenger receptor B2, whereas those with glutamine (Q) or glycine (G) are not. However, the contribution of this variation to pathogenesis in humans is not fully understood. We compared the virulence of VP1-145E and VP1-145G viruses of Isehara and C7/Osaka backgrounds in cynomolgus monkeys. VP1-145E, but not VP1-145G, viruses induced neurological symptoms. VP1-145E viruses were frequently detected in the tissues of infected monkeys. VP1-145G viruses were detected less frequently and disappeared quickly. Instead, mutants that had a G-to-E mutation at VP1-145 emerged, suggesting that VP1-145E viruses have a replication advantage in the monkeys. This is consistent with our hypothesis proposed in the accompanying paper (K. Kobayashi, Y. Sudaka, A. Takashino, A. Imura, K. Fujii, and S. Koike, J Virol 92:e00681-18, 2018, https://doi.org/10.1128/JVI.00681-18) that the VP1-145G virus is attenuated due ...Continue Reading

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Citations

Aug 2, 2019·Future Microbiology·Xingjian WenAnchun Cheng
Dec 12, 2018·Nature Microbiology·Daming ZhouDavid I Stuart
Jan 12, 2020·Journal of Biomedical Science·Kyousuke Kobayashi, Satoshi Koike
Sep 5, 2019·Journal of Biomedical Science·Jing-Yi LinShin-Ru Shih
Mar 11, 2020·Frontiers in Microbiology·Bo-Shiun ChenShin-Ru Shih
Dec 16, 2018·Virologica Sinica·Huiqiang Wang, Yuhuan Li
Jan 17, 2021·Journal of Biomedical Science·Mohd Ishtiaq AnasirChit Laa Poh
Feb 2, 2021·Frontiers in Microbiology·Chih-Shin ChangChiaho Shih
Nov 14, 2020·Expert Review of Anti-infective Therapy·Han Kang TeeYoke Fun Chan
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Mar 23, 2021·Emerging Microbes & Infections·Pei Yi AngSylvie Alonso
Mar 20, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jiaolian TangHongchao Jiang
Aug 29, 2021·Viruses·Kyousuke Kobayashi, Satoshi Koike
Nov 3, 2021·The Journal of Experimental Medicine·Jie ChenShen-Ying Zhang
Jan 13, 2022·Chemistry, an Asian Journal·Ujjyani GhoshAsim Bhaumik

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