Vpx association with mature core structures of HIV-2

Virology
V Kewalramani, M Emerman

Abstract

Vpx is a virion-incorporated protein encoded by HIV-2 and certain strains of SIV which is necessary for efficient infection of lymphocytes and macrophages. To determine the location of Vpx within the HIV-2 particle, core structures were obtained from mature HIV-2 virions. Analysis of purified cores reveal the presence of monomeric Vpx as well as a nondenaturable and nonreducible higher order Vpx complex. Characterization of the core-associated Vpx complex suggests it to be a Vpx homodimer, indicative of high concentrations of Vpx. The incorporation and concentration of Vpx in HIV-2 cores support the hypothesis that it functions within the viral preintegration complex.

Citations

Oct 19, 2012·The Journal of Biological Chemistry·Gregory BergerAndrea Cimarelli
Aug 15, 1997·The EMBO Journal·T M FletcherB H Hahn
Sep 22, 2006·Journal of Virology·Prabhat K SinghalSundarasamy Mahalingam
Nov 9, 2000·Journal of Virology·A Ohagen, D Gabuzda
Apr 13, 2010·Retrovirology·Diana AyindeFlorence Margottin-Goguet
Aug 15, 2012·Retrovirology·Steven SantosSergey Iordanskiy
Nov 23, 2011·Journal of Visualized Experiments : JoVE·Vaibhav B Shah, Christopher Aiken
May 1, 2006·Current Opinion in HIV and AIDS·Christopher Aiken
Jan 31, 2002·AIDS·P J Bock, D M Markovitz
Feb 7, 2006·Virology·Lisa A MahnkeLee Ratner
May 2, 2014·Frontiers in Microbiology·Torsten SchallerCaroline Goujon
Aug 21, 2003·Journal of Molecular Biology·P Rajendra KumarS Mahalingam
Mar 13, 2015·Journal of Virology·Paula JáureguiNathaniel R Landau
Jun 6, 2008·The Journal of Biological Chemistry·Erwann Le RouzicFlorence Margottin-Goguet
Jun 7, 2019·Journal of Virology·Mohammad Adnan SiddiquiMasahiro Yamashita
Jul 20, 2006·The Journal of Biological Chemistry·Christelle Vauloup-FellousArielle R Rosenberg
Feb 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hanna-Mari BaldaufOliver T Keppler
Mar 12, 1999·Journal of Virology·S M WhiteV Planelles
May 30, 1998·Journal of Virology·H A Pancio, L Ratner
Sep 11, 1999·Journal of Virology·A KotovC Aiken
Nov 24, 2004·The Journal of Biological Chemistry·Palakurthy Rajendra KumarSundarasamy Mahalingam
Oct 27, 2021·PLoS Pathogens·Michaël M MartinFlorence Margottin-Goguet

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