PMID: 7517959May 1, 1994Paper

VS38: a new monoclonal antibody for detecting plasma cell differentiation in routine sections

Journal of Clinical Pathology
H TurleyK Gatter

Abstract

To characterise a new mouse monoclonal antibody, VS38, which recognises an intracytoplasmic antigen of 64 kilodaltons present in normal and neoplastic plasma cells; and to establish its value as a diagnostic reagent for routine pathological practice. A range of normal and neoplastic tissue sections, both frozen and routinely fixed, were immunostained, using the microwave method of antigen retrieval for routinely fixed specimens. The antibody was also tested on blood and bone marrow specimens and a range of human cell lines. The molecular weight of the antigen recognised by the antibody was obtained by western blot analysis. FACS analysis was used to demonstrate the cellular location of the antigen and its presence on tonsil cell suspensions and myeloma cases. VS38 recognised normal and neoplastic plasma cells in all of the tissues, including all routinely fixed plasma cell neoplasms tested. The antibody also weakly stained epithelial elements within the tissue but was absent from haemopoietic cells of other lineages. Antibody VS38 is of potential value in identifying myeloma or plasmacytoma in bone marrow or other tissues. It differentiates lymphoplasmacytoid lymphoma from lymphocytic and follicular lymphoma. It also subdivides...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1988·Cold Spring Harbor Symposia on Quantitative Biology·J M HorowitzE Harlow
Mar 1, 1989·Cancer·M D LindenH Park
Jul 1, 1985·Southern Medical Journal·D E Keim, J W Geltner
Oct 1, 1985·The British Journal of Dermatology·H J DoddT J Chambers
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason
Nov 1, 1983·Clinical Immunology and Immunopathology·M KamounJ A Hansen
Aug 15, 1982·Cancer·R A WarnkeR F Dorfman

❮ Previous
Next ❯

Citations

Jun 27, 2012·Der Pathologe·K J Schmitz, U Schade
Aug 11, 2005·Current Oncology Reports·Julie Teruya-Feldstein
Jul 1, 2005·Cell Research·Raymond A DanielsGavin R Screaton
Dec 4, 2002·Histopathology·W G McCluggage, V P Sumathi
Sep 10, 2003·The American Journal of Surgical Pathology·Laurence de LevalNancy Lee Harris
Aug 21, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Po Hao FengYing-Huang Tsai
Mar 1, 1996·Journal of Clinical Pathology·J H Shanks, S S Banerjee
Jun 1, 1997·Journal of Clinical Pathology·J L GalaJ M Scheiff
Jun 5, 2003·Journal of Clinical Pathology·A Wei, S Juneja
Jun 26, 2007·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Falko Fend, Markus Kremer
Jan 1, 1997·Pathology, Research and Practice·I SulzbacherS Lang
Dec 1, 2010·Surgical Pathology Clinics·Robert B Lorsbach
Mar 16, 2011·Journal of Medical Primatology·Joshua A KramerKeith G Mansfield
Nov 16, 2004·Journal of Immunological Methods·Hisae NikiToshiaki Tagawa
Jul 5, 2001·The American Journal of Pathology·K L SummersD N Hart
Jan 29, 2000·The Annals of Otology, Rhinology, and Laryngology·M Ivarsson, C Lundberg
Nov 18, 2003·The British Journal of Dermatology·I NicolM A Richard
Jan 10, 1998·The Journal of Pathology·C Copie-BergmanP G Isaacson
Apr 22, 1999·The Journal of Pathology·H TurleyK C Gatter
Jul 17, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y NatkunamM van De Rijn
Apr 25, 2007·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Bernhard FischerHansdetlef Wassmann
Sep 29, 2020·Journal of Clinical and Experimental Hematopathology : JCEH·Haruo OhtaniMasaaki Miyazawa
Aug 5, 2000·The Journal of Pathology·D Y MasonM Jones
May 17, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·I A LampertA C Wotherspoon
Jun 12, 2019·International Journal of Hematology·Shumpei MizutaMitsumasa Watanabe
Jul 14, 1998·American Journal of Hematology·T C ChenC F Hung
Oct 6, 2020·Cytometry. Part B, Clinical Cytometry·Kah Teong SohPaul K Wallace
Feb 15, 2001·Archives of Pathology & Laboratory Medicine·Y LinM A Vasef
Jul 24, 2004·Archives of Pathology & Laboratory Medicine·Andreas ErbersdoblerGuntram Lock
Jul 24, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Ágnes CzetiGábor Barna
Jun 29, 2005·Annales de pathologie·Jean-Philippe DalesColette Taranger-Charpin
Oct 14, 2021·American Journal of Clinical Pathology·Annemiek BroijlVincent H J van der Velden

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.