VTX-1 Liquid Biopsy System for Fully-Automated and Label-Free Isolation of Circulating Tumor Cells with Automated Enumeration by BioView Platform

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
Elodie Sollier-ChristenSteve C Crouse

Abstract

Clinicians continue to rely on invasive tissue biopsies as a mean to assess a patient's disease and prescribe appropriate treatment regimens. Biopsies not only are risky and expensive but also limit the understanding of disease. Circulating tumor cells (CTCs) can be isolated from a simple blood draw and offer a promising potential to both diagnose and monitor cancer progression. The VTX-1 Liquid Biopsy System automates the isolation of clinically relevant CTC populations, while simplifying their collection for easy analysis, ultimately expanding the clinical possibilities for CTCs. We present here the key features and performance of this automated system for isolating CTCs directly from whole blood, both with cell spiking experiments and patient samples. As a first step toward the characterization of CTCs for research applications and transfer to clinical practice, we present workflows for both molecular analyses and automated cell enumeration and biomarker quantification with the BioView imaging platform. © 2018 The Authors. Cytometry Part A published by Wiley Periodicals, Inc. on behalf of International Society for Advancement of Cytometry.

References

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Citations

Aug 1, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Camille RaillonPhilippe Renaud
Jun 18, 2019·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Jessica P Houston
Feb 14, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Nicolas GuibertJulien Mazieres
Mar 1, 2019·Cancers·Véronique HofmanPaul Hofman
Mar 4, 2021·Cancers·Amelia J RushtonR Charles Coombes
May 1, 2021·Cancers·Antonella De LucaNicola Normanno

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Methods Mentioned

BETA
biopsies
Biopsy
chip
blood draw

Software Mentioned

CellSearch
Vortex
BioView System
BioView
VTX

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