PMID: 8997504Dec 23, 1996Paper

Vulnerability of CA1 neurons to glutamate is developmentally regulated

Brain Research. Developmental Brain Research
J D MarksG G Haddad

Abstract

Although it is well documented that glutamate receptor subtypes are differentially expressed during central nervous system development postnatally, how glutamate affects neurons during postnatal development is unclear. We therefore examined the development of the intrinsic neuronal response to glutamate receptor activation by studying single, hippocampal CA1 neurons that had been acutely dissociated from newborn (P1-3), 1 week old (P6-8), and 3 week old (P21-25) rats. Using laser scanning confocal microscopy and the calcium dye Fluo-3, we made time-lapse studies of the effects of glutamate stimulation on free intracellular calcium ([Ca2+]i) and simultaneous changes in neuronal morphology. In P21-25 neurons, glutamate increased [Ca2+]i fluorescence, and caused marked somal swelling, blebbing, and retraction of dendrites into the soma. These major morphological changes were followed by sudden loss of intracellular fluorescence, indicative of a loss of membrane integrity and cell death. In P6-8 neurons, glutamate increased [Ca2+]i to the same extent, but this increase was not followed by either major morphological changes or loss of membrane integrity. In P1-3 neurons, glutamate increased [Ca2+]i minimally, and no morphologic chan...Continue Reading

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Citations

May 9, 2012·Reviews in Endocrine & Metabolic Disorders·Joseph Nuñez
Aug 12, 2003·Cell Calcium·Mark Arundine, Michael Tymianski
Dec 13, 2000·Brain Research. Developmental Brain Research·J D MarksX M Zhang
Jun 26, 2001·Epilepsia·G L Holmes
Nov 22, 2005·Acta Paediatrica·Minna AaltonenPekka O Kääpä
Mar 4, 2003·Journal of Cellular and Molecular Medicine·B O PopescuL M Popescu
Dec 25, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Paula Steffen AlvarezMagda Lahorgue Nunes
May 10, 2011·Brain & Development·Hideaki KanemuraMasao Aihara
Feb 2, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anne Pereira de VasconcelosAstrid Nehlig
Nov 18, 2006·Lancet Neurology·Yehezkel Ben-Ari, Gregory L Holmes
Sep 14, 2004·Mental Retardation and Developmental Disabilities Research Reviews·Gregory L Holmes
Jul 17, 2004·Journal of Cellular and Molecular Medicine·E C Toescu, A Verkhratsky
Jun 16, 2007·Epilepsia·Cesare T Lombroso
Jul 21, 2004·Seminars in Pediatric Neurology·James J Riviello, Gregory L Holmes
Sep 1, 2006·Developmental Neuroscience·Courtney L RobertsonGary Fiskum
Apr 2, 2002·Neuroreport·Gregory L HolmesYehezkiel Ben-Ari
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Nov 12, 2020·Expert Review of Neurotherapeutics·Francesco PisaniCarlotta Spagnoli
Aug 10, 2004·The Journal of Experimental Biology·Philip E Bickler

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