Vulnerability of the developing airway.

Respiratory Physiology & Neurobiology
Abhrajit Ganguly, Richard J Martin

Abstract

Longer term respiratory morbidity is a frequent concern for former preterm infants. Increased airway reactivity and wheezing disorders are extremely common in this population, both in infants who meet diagnostic criteria for bronchopulmonary dysplasia [BPD], and in the absence of this diagnosis. It is, therefore, imperative to gain a better understanding of normal and abnormal postnatal development of the immature airway. Airway hyperreactivity may be secondary to abnormal bronchoalveolar attachments in the face of parenchymal lung injury, or secondary to an imbalance between constrictor and dilator neural pathways. Finally, the airway itself may undergo functional and/or structural changes, including increased airway smooth muscle mass, and changes in airway extracellular matrix which may, in turn, modulate downstream signaling pathways to hyperoxia or pressure exposed vulnerable airways.

Citations

Oct 10, 2019·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ettore LignelliRory E Morty
Oct 23, 2020·Expert Review of Respiratory Medicine·Marta SchiliroChristina Pabelick
Oct 14, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Richard J MartinEduardo Bancalari

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