Vulvar Lichen Sclerosus and Neoplastic Transformation: A Retrospective Study of 976 Cases

Journal of Lower Genital Tract Disease
L MichelettiChiara Benedetto

Abstract

The aim of the study was to estimate the neoplastic potential of vulvar lichen sclerosus (VLS). This was a retrospective study of 976 women with VLS. We recorded age at diagnosis of VLS, length of follow-up, and type of neoplasia, categorized as the following: (1) vulvar intraepithelial neoplasia (VIN), further subdivided in differentiated VIN (dVIN) and high-grade squamous intraepithelial lesion; (2) superficially invasive squamous cell carcinoma; and (3) frankly invasive squamous cell carcinoma. Neoplasia incidence risk, neoplasia incidence rate, and cumulative probability of progression to neoplasia according to the Kaplan-Meier method were estimated. Log-rank test was used to compare the progression-free survival curves by age at diagnosis of VLS. The mean age at diagnosis of VLS was 60 (median = 60; range = 8-91) years. The mean length of follow-up was 52 (median = 21; range = 1-331) months. The following 34 patients developed a neoplasia: 8 VIN (4 dVIN, 4 high-grade squamous intraepithelial lesions), 6 keratinizing superficially invasive squamous cell carcinoma (5 with adjacent dVIN), and 20 keratinizing invasive squamous cell carcinoma (1 with adjacent dVIN). The neoplasia incidence risk was 3.5%. The neoplasia incidence...Continue Reading

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Citations

Mar 11, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·E A DellR R Torgerson
Jan 10, 2018·The British Journal of Dermatology·F M LewisL S Exton
Mar 1, 2019·Journal of Lower Genital Tract Disease·Stefano BasilePierluigi Benedetti Panici
Apr 24, 2020·Journal of Lower Genital Tract Disease·Angela LinJames Scurry
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Oct 21, 2021·Journal of Lower Genital Tract Disease·Andreia AlbuquerquePedro Vieira-Baptista

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