Waist circumference as a screening tool for cardiovascular risk factors: evaluation of receiver operating characteristics (ROC)

Obesity Research
T S HanM E Lean

Abstract

To evaluate the receiver operating characteristics (ROC) to determine the cutoffs of waist circumference as a potential population directed screening tool for hypercholesterolaemia (> or = 6.5 mmol/L), low high density lipoprotein cholesterol (< 0.9 mmol/L), and hypertension (treated and/or systolic > or = 160 and/or diastolic blood pressure > or = 95 mmHg), in 2183 men and 2698 women aged 20 to 59 years selected at random from Dutch civil registries. Height, weight, body mass index (BMI), waist circumference, total plasma cholesterol and high density lipoprotein cholesterol concentrations, and blood pressure. ROC curves showed that sensitivity equalled specificity at waist circumferences between 93-95 cm in men and 81-84 cm in women for identifying individual risk factors, and 92 cm in men and 81 cm in women for identifying those with at least one risk factor. Sensitivity and specificity were equal at levels between 61% to 69% for identifying individual risk factors, with positive predictions (56.8% in men and 37.8% in women) within 2% of those using previously defined 'Action Level 1' of waist circumference 94 cm in men and 80 cm in women (58.8% in men and 37.4% in women). Risk prediction by anthropometric methods was relativ...Continue Reading

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