Waist circumference as an independent risk factor for NODAT

Annals of Transplantation : Quarterly of the Polish Transplantation Society
Ivana DedinskáMarián Mokáň

Abstract

New-onset diabetes mellitus after transplantation (NODAT) is a serious and frequent complication of solid organ transplantations. NODAT leads to 2-3 times higher cardiovascular morbidity and mortality. Visceral obesity is a key factor for diabetes mellitus type 2 and metabolic syndrome development, and is an independent risk factor for cardiovascular diseases. The series consisted of 167 patients after primary kidney transplantation from a dead donor (64 patients had developed NODAT), average age of the series was 46.1±11.6 years. We retrospectively examined waist circumference, body mass index, and weight gain in the 12th month after transplantation. We examined average level of triglycerides, cholesterol, and immunosuppression throughout the 12 monitored months. Patients with NODAT were significantly older (P=0.004) and had greater waist circumference (P<0.0001) and higher average sirolimus level (P=0.0262). We identified the following independent risk factors for NODAT by using multivariate analysis: age at the time of transplantation above 50 years (HR=2.5038, [95% CI: 1.7179 to 3.6492], P<0.0001), waist circumference in men greater than 94 cm (HR=1.9492, [95% CI: 1.1697 to 3.2480], P=0.0104) and in women greater than 80 cm...Continue Reading

Citations

Nov 26, 2015·Journal of Diabetes and Its Complications·Peter ĎurdíkMiriam Čiljaková
Jul 7, 2016·Diabetes & Metabolic Syndrome·I DedinskáM Mokáň
Mar 25, 2016·World Journal of Transplantation·Minh-Ha TranHirohito Ichii
May 1, 2021·Frontiers in Medicine·Clara García-CarroMaria José Soler

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