Waist-to-height ratio as a marker of low-grade inflammation in obese children and adolescents

Journal of Pediatric Endocrinology & Metabolism : JPEM
Carolina CaminitiCarmen S Mazza

Abstract

The epidemic of childhood obesity is associated with early atherosclerosis. Several reports have related this event to low-grade inflammation described in obesity. CRP and IL6 are markers that correlate with adiposity. The waist-to-height ratio (WtHR) is an anthropometric marker associated with insulin resistance and inflammation. The objective of this study was to assess the correlation between WtHR, metabolic complications and pro-inflammatory factors in obese children and adolescents. Weight, height, waist circumference, glycemia, insulin, CRP, TNF-α and IL-6 were measured in the baseline sample in 280 patients 6-19 years of age with overweight or obesity (OW/OB) and 112 normal-weight controls. Logistic regression was performed using WtHR as an independent variable. p>0.05 STATA11. Mean WtHR was 0.6±0.06 in OW/OB and 0.43±0.02 in controls (p<0.01). WtHR was increased in 93% of the OW/OB vs. 2% of the controls. In the OW/OB inflammatory markers were significantly increased (p<0.01) compared to the controls (CRP 2.2 vs. 0.8; Il-6 2.9 vs. 2.1; and TNF-α 6.2 vs. 5.5). In the WtHR>0.5, insulin resistence and inflammatory markers were significantly increased (p<0.01) compared to the WtHR<0.5 (HOMA 3.4 vs. 1.4; CRP 2.3 vs. 0.6; Il-...Continue Reading

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Citations

Oct 27, 2016·Annals of Human Biology·Edmar Lacerda MendesJorge Mota
Jun 3, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jeerunda SantiprabhobRungsunn Tungtrongchitr
Oct 18, 2018·Chinese Journal of Integrative Medicine·Xian-Pei HengSu-Ping Huang
Jan 19, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Mohd Ashraf GanieSyed Mudassar
May 27, 2021·BMC Gastroenterology·Guotai ShengYang Zou

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