Waiting to be born: the ethical implications of the generation of "NUBorn" and "NUAge" mice from pre-pubertal ovarian tissue.

The American Journal of Bioethics : AJOB
Laurie ZolothTeresa K Woodruff

Abstract

Oncofertility is one of the 9 NIH Roadmap Initiatives, federal grants intended to explore previously intractable questions, and it describes a new field that exists in the liminal space between cancer treatment and its sequelae, IVF clinics and their yearning, and basic research in cell growth, biomaterials, and reproductive science and its tempting promises. Cancer diagnoses, which were once thought universally fatal, now often entail management of a chronic disease. Yet the therapies are rigorous, must start immediately, and in many cases result in premature failure of the body's reproductive ability. In women, this loss is especially poignant; unlike the routine storage of sperm, which is done in men and boys facing similar treatment decisions, freezing oocytes in anticipation of fertility loss is not possible in most cases, and creating an embryo within days of diagnosis raises significant moral, social and medical challenges. Oncofertility is the study of how to harvest ovarian tissue in women facing cancer to preserve their gametes for future use with IVF, thus allowing the decisions about childbearing to be deferred and reproductive choices to be preserved. The research endeavor uses the capacity of the ovarian follicle ...Continue Reading

References

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May 24, 2007·Tissue Engineering·Min XuTeresa K Woodruff
Mar 21, 2008·Qualitative Health Research·Wendy AustinErika Goble

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Citations

Apr 14, 2010·Journal of Assisted Reproduction and Genetics·Shauna L GardinoTeresa K Woodruff
Aug 27, 2013·Journal of Assisted Reproduction and Genetics·Teresa K Woodruff
May 26, 2010·Nature Reviews. Clinical Oncology·Teresa K Woodruff
Jun 2, 2012·The American Journal of Bioethics : AJOB·Gwendolyn P QuinnDevin Murphy
Jan 15, 2014·Bone Marrow Transplantation·S JoshiN S Majhail
Mar 22, 2014·Journal of Assisted Reproduction and Genetics·Francesca E DuncanTeresa K Woodruff
Aug 30, 2008·The American Journal of Bioethics : AJOB·Cynthia B Cohen
May 12, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jennifer LevineCatharyn J Stern
Jul 7, 2016·Medicine, Science, and the Law·P VoultsosB Tarlatzis

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