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Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels

The Journal of Biological Chemistry

Sep 20, 2011

Susanna ZierlerAndrea Fleig

Abstract

Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnesium-uptake mechanism in mammalian cells and are key regulators of cell growth and proliferation. They are expressed abundantly in a variety of human carcinoma cells controlling survival, growth, and mig...read more

Mentioned in this Paper

T-Lymphocyte
Acute Basophilic Leukemia
HEK293 Cells
Coral
Trpm7
Magnesium Measurement
CLU gene
Waixenicin A
Protoplasm
Analog
1
58
Paper Details
References
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  • Citations47
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  • References51
  • Citations47
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Waixenicin A inhibits cell proliferation through magnesium-dependent block of transient receptor potential melastatin 7 (TRPM7) channels

The Journal of Biological Chemistry

Sep 20, 2011

Susanna ZierlerAndrea Fleig

PMID: 21926172

DOI: 10.1074/jbc.m111.264341

Abstract

Transient receptor potential melastatin 7 (TRPM7) channels represent the major magnesium-uptake mechanism in mammalian cells and are key regulators of cell growth and proliferation. They are expressed abundantly in a variety of human carcinoma cells controlling survival, growth, and mig...read more

Mentioned in this Paper

T-Lymphocyte
Acute Basophilic Leukemia
HEK293 Cells
Coral
Trpm7
Magnesium Measurement
CLU gene
Waixenicin A
Protoplasm
Analog
1
58

Similar Papers Found In These Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Organellar TRP channels

Orangellar TRP channels are transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. Discover the latest research on organellar TRP channels here.

Related Papers

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]

Inhibition of TRPM7 channels prevents proliferation and differentiation of human lung fibroblasts

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]August 13, 2013
Mingzhe YuJun Li
Paper Details
References
  • References51
  • Citations47
12345...
  • References51
  • Citations47
12345
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