Wake promoting effects of cocaine and amphetamine-regulated transcript (CART).

Neuropeptides
Glenda L KeatingDavid B Rye

Abstract

Cocaine- and amphetamine-regulated transcript (CART) peptides modulate anxiety, food intake, endocrine function, and mesolimbic dopamine related reward and reinforcement. Each of these disparate behaviors takes place during the state of wakefulness. Here, we identify a potential wake promoting role of CART by characterizing its effects upon sleep/wake architecture in rats. Dose-dependent increases in wake were documented following intracerebroventricular CART 55-102 administered at the beginning of the rat's major sleep period. Sustained wake was observed for up to 4h following delivery of 2.0 microg of CART peptide. The wake promoting effect was specific to active CART 55-102 because no effect on sleep/wake was observed with the inactive form of the peptide. Increased wake was followed by robust rebound in NREM and REM sleep that extended well into the subsequent lights-off, or typical wake period, of the rat. These findings point to a potential novel role for CART in regulating wakefulness.

References

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Citations

Jan 29, 2014·Peptides·Nishikant K SubhedarDadasaheb M Kokare
Jul 18, 2014·Annual Review of Neuroscience·Constance RichterAlexander F Schier
Mar 14, 2013·American Journal of Physiology. Endocrinology and Metabolism·Amanda LaqueHeike Münzberg
Mar 13, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Weihong Pan, Abba J Kastin
Oct 5, 2018·Brain Structure & Function·Fumito NaganumaRamalingam Vetrivelan
Dec 10, 2020·International Journal of Molecular Sciences·Matthias KreuzerPaul S García

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