Wake-Up Stroke versus Stroke with Known Onset Time: Clinical and Multimodality CT Imaging Characteristics

Cerebrovascular Diseases
Jan W Dankbaaron behalf of the DUST investigators

Abstract

Current guidelines for the treatment of acute ischemic stroke are mainly based on the time between symptom onset and initiation of treatment. This time is unknown in patients with wake-up stroke (WUS). We investigated clinical and multimodality CT imaging characteristics on admission in patients with WUS and in patients with a stroke with a known onset time. All patients were selected from a large prospective cohort study (Dutch acute stroke study). WUS patients last seen well > 4.5 and ≤4.5 h were separately compared to patients with a known onset time ≤4.5 h. In addition, WUS patients with a proximal occlusion of the anterior circulation last seen well > 6 and ≤6 h were separately compared to patients with a known onset time ≤6 h and a proximal occlusion. National Institute of Health Stroke Score, age, gender, history of atrial fibrillation, non-contrast CT (NCCT) Alberta Stroke Program Early CT Score (ASPECTS), CT-perfusion abnormalities, proximal occlusions, and collateral filling on CT angiography were compared between groups using the Mann-Whitney U test and Fisher's exact test. WUS occurred in 149/1,393 (10.7%) patients. Admission clinical and imaging characteristics of WUS patients last seen well > 4.5 h (n = 81) were n...Continue Reading

References

Feb 24, 2006·Cerebrovascular Diseases·Kenichi TodoHiroaki Naritomi
Jul 12, 2008·Stroke; a Journal of Cerebral Circulation·Volker PuetzAndrew M Demchuk
Sep 26, 2008·The New England Journal of Medicine·Werner HackeUNKNOWN ECASS Investigators
Dec 26, 2008·Stroke; a Journal of Cerebral Circulation·Jean-Marc OlivotGregory W Albers
May 11, 2011·Neurology·J MackeyJ P Broderick
Oct 8, 2011·Stroke; a Journal of Cerebral Circulation·Bruce C V CampbellMark W Parsons
Dec 3, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Luisa RoveriGiancarlo Comi
Mar 16, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Götz ThomallaUNKNOWN WAKE-UP investigators
Feb 12, 2015·The New England Journal of Medicine·Bruce C V CampbellUNKNOWN EXTEND-IA Investigators
Feb 12, 2015·The New England Journal of Medicine·Mayank GoyalUNKNOWN ESCAPE Trial Investigators
Apr 18, 2015·The New England Journal of Medicine·Jeffrey L SaverUNKNOWN SWIFT PRIME Investigators
Apr 18, 2015·The New England Journal of Medicine·Tudor G JovinUNKNOWN REVASCAT Trial Investigators
Aug 20, 2015·The Neurohospitalist·Mark N Rubin, Kevin M Barrett
Sep 16, 2015·Internal and Emergency Medicine·Nicola MorelliDonata Guidetti
Oct 21, 2015·Cerebrovascular Diseases·Tom van SeetersUNKNOWN Dutch acute stroke study (DUST) investigators
Dec 8, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ricardo CostaCarla Ferreira
Dec 1, 2014·Journal of Neurology and Neurological Disorders·M C DennyS Martin-Schild
Sep 28, 2016·JAMA : the Journal of the American Medical Association·Jeffrey L SaverUNKNOWN HERMES Collaborators
Nov 14, 2017·The New England Journal of Medicine·Raul G NogueiraUNKNOWN DAWN Trial Investigators
Jan 25, 2018·The New England Journal of Medicine·Gregory W AlbersUNKNOWN DEFUSE 3 Investigators

❮ Previous
Next ❯

Citations

Oct 19, 2019·Journal of the American Heart Association·Joong-Goo KimUNKNOWN on the behalf of CRCS‐K Investigators <xref ref-type="author-note" rid="jah34526-note-0001"><sup>†</sup></xref>
Dec 9, 2020·International Journal of Nursing Practice·Charlotte MillardKate Rowan-Robinson
Mar 2, 2021·The Neurologist·Roberta A Pozzi-MucelliMaria A Cova
Apr 2, 2021·Frontiers in Neurology·Patrick D LydenBerislav V Zlokovic
Mar 28, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Brian Mac GroryMatthew Schrag
May 15, 2021·Journal of Healthcare Engineering·Jin Tong, Wangda Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.