Wakefulness during the induction with high-dose fentanyl and oxygen anesthesia

Journal of Anesthesia
A WatanabeM Aoki

Abstract

The purpose of this study was to investigate the state of wakefulness during the induction of anesthesia with high-dose fentanyl using the isolated forearm technique. Ten patients scheduled for elective cardiovascular surgery were premedicated with morphine (0.15 mg/kg) and scoploamine (0.3-0.4 mg) intramuscularly one hour before induction. The induction of anesthesia was performed by intravenous administration of 100 micro g/kg of fentanyl in 15 min or over. The pneumatic tourniquet applied on the left upper arm was inflated to 220-240 mmHg after 10 micro g/kg of fentanyl was given and then pancuronium was administered. Verbal commands were given to the patient after 25, 50, 75 and 100 micro g/kg of fentanyl was administered. Eight patients out of 10 responded to the verbal commands after administration of 25 micro g/kg of fentanyl. Six patients also responded after administration of 100 micro g/kg of fentanyl and diazepam 5 mg was given to prevent tachycardia and rigidity during endotracheal intubation. Muscle rigidity and tachycardia were noticed in three and four patients respectively. These complications disappeared by diazepam administration. It was noted that wakefulness frequently occurred during the induction by high-d...Continue Reading

References

Apr 1, 1977·The International Journal of Clinical and Experimental Hypnosis·R TrustmanR Titley
May 21, 1977·British Medical Journal·M E Tunstall
Oct 1, 1976·Anesthesiology·M J FruminM E Jarvik
Jul 1, 1983·Anesthesia and Analgesia·K C Wong
Dec 1, 1980·Anesthesia and Analgesia·N MummaneniA Montoya
May 1, 1981·Anesthesia and Analgesia·M K ComstockW C Stevens

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Citations

Dec 17, 2015·Journal of Anesthesia·Marco CascellaArturo Cuomo
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Anthony G MessinaNathan Leon Pace

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