Abstract
Acute leukemia was observed to develop in three patients with Waldenstöm macroglobulinemia. Each patient had been treated with cytotoxic drug therapy. Pancytopenia preceded the onset of the terminal leukemia in two of the three cases. The acute leukemias were all of acute myelogenous type. All of the patients died soon after the development of the terminal leukemia. A number of recent reports have documented acute terminal leukemia in patients with macroglobulinemias and multiple myeloma, as well as other malignant and nonmalignant diseases. The role of the cytotoxic drugs, especially chlorambucil, cyclophosphamide, and melphalan, in leukemogenesis has been raised by these recent reports.
References
Jan 1, 1979·Medicine·D A Casciato, J L Scott
Nov 1, 1979·Cancer·A I PickJ Pinkhas
Apr 1, 1977·Blood·M R MacKenzie, T K Lee
Mar 1, 1975·The American Journal of Medicine·F Rosner, H Grünwald
Apr 29, 1972·The Medical Journal of Australia·I J Forbes
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Mar 22, 1980·Lancet·Y LebranchuD Buriot
Jan 1, 1980·Acta Haematologica·J P AymardR Herbeuval
Feb 19, 1981·The New England Journal of Medicine·P D BerkL R Wasserman
Dec 15, 1982·Cancer·L F SkinniderG Armitage
Jul 1, 1959·Archives of Biochemistry and Biophysics·F W PUTNAMR A PHELPS
Citations
Jan 1, 1988·Springer Seminars in Immunopathology·D Geltner
Jul 1, 1995·Critical Reviews in Oncology/hematology·E Pascali
Oct 5, 1985·Lancet·M Lough
Dec 1, 1989·Journal of Internal Medicine·M T PetrucciF Mandelli
Nov 1, 1993·Annals of Hematology·R W van der HulstA Brand
Apr 30, 2003·Seminars in Oncology·Donna M WeberRaymond Alexanian
Oct 29, 2002·Leukemia & Lymphoma·Morie A Gertz
Apr 1, 1993·Leukemia & Lymphoma·G Majumdar, N G Slater
Jan 11, 1991·Cancer Investigation·D C CaseD L Redfield
Jul 13, 2001·American Journal of Clinical Pathology·C M RosalesL J Medeiros
Aug 4, 2007·British Journal of Haematology·Rafael Fonseca, Suzanne Hayman
Apr 10, 2007·Leukemia Research·K J PhekooUNKNOWN South Thames Haematology Specialist Committee
Jun 18, 2004·Leukemia·R A MadanB Kasimis
Jan 23, 2009·The Cochrane Database of Systematic Reviews·Kun YangTaixiang Wu
Dec 22, 1998·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·K OoharaA Kobayashi
Jan 18, 1990·The New England Journal of Medicine
Jun 2, 2005·American Journal of Hematology·Morie A Gertz
Dec 5, 2020·Leukemia·Lisa Marie KaiserChristian Buske
Apr 4, 2021·Cancers·Ramón García-Sanz, Cristina Jiménez
Jan 1, 1988·Critical Reviews in Oncology/hematology·R A Kyle, P A Greipp