Walking disability measures in multiple sclerosis patients: Correlations with MRI-derived global and microstructural damage

Journal of the Neurological Sciences
Dejan JakimovskiRobert Zivadinov

Abstract

The relationship between walking disability in multiple sclerosis (MS) patients and their macro- and microstructural MRI-derived measures still remains unclear. To assess the correlations between walking disability and MRI-derived lesion, atrophy, and microstructural/axonal integrity outcomes. Seventy-one (71) MS patients were clinically examined, the expanded timed get-up and go (ETGUG), and timed 25-foot walk (T25FW) tests were assessed. Additionally, the Symbol Digit Modalities Test (SDMT) was obtained. Normalized brain (NBV), gray matter (GMV), white matter (WMV), cortex (CV), and deep GM (DGM) volumes, as well as lesion volumes (LV) and diffusion tensor imaging (DTI) scalar maps of fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity were calculated. Spearman correlation, partial correlation and stepwise regression analyses were performed. T25FW and ETGUG were associated with T2-LV (p < .001), global (NBV, p < .001), tissue-specific (GMV and CV, p < .001) and regional (DGM p < .001; and thalamus p < .001) volumes. The ETGUG remained correlated with T1-LV, GMV, CV and total DGM volume (all p < .001) after age, sex, and disease duration adjustment. The WMV was not associated with walking disabil...Continue Reading

Citations

Apr 21, 2019·Expert Review of Neurotherapeutics·Dejan JakimovskiRobert Zivadinov
Aug 23, 2019·Annals of Clinical and Translational Neurology·Dejan JakimovskiRobert Zivadinov
Feb 6, 2020·Vaccines·Dejan JakimovskiRobert Zivadinov
May 12, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Dejan JakimovskiMichael G Dwyer
May 28, 2019·Frontiers in Aging Neuroscience·Dejan JakimovskiRalph H B Benedict
Oct 13, 2020·Journal of Magnetic Resonance Imaging : JMRI·Niels BergslandRobert Zivadinov
Jul 17, 2019·Journal of Clinical Lipidology·Richard W BrowneMurali Ramanathan
Jul 20, 2020·Multiple Sclerosis and Related Disorders·Mason McCombMurali Ramanathan
May 1, 2021·International Journal of Environmental Research and Public Health·Jessica F Baird, Robert W Motl
Jun 28, 2021·Journal of the Neurological Sciences·Dejan JakimovskiBianca Weinstock-Guttman
Oct 26, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Maria PetraccaMatilde Inglese

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