Walking Exercise Therapy Effects on Lower Extremity Skeletal Muscle in Peripheral Artery Disease.

Circulation Research
Mary M McDermottLuigi Ferrucci

Abstract

Walking exercise is the most effective noninvasive therapy that improves walking ability in peripheral artery disease (PAD). Biologic mechanisms by which exercise improves walking in PAD are unclear. This review summarizes evidence regarding effects of walking exercise on lower extremity skeletal muscle in PAD. In older people without PAD, aerobic exercise improves mitochondrial activity, muscle mass, capillary density, and insulin sensitivity in skeletal muscle. However, walking exercise increases lower extremity ischemia in people with PAD, and therefore, mechanisms by which this exercise improves walking may differ between people with and without PAD. Compared with people without PAD, gastrocnemius muscle in people with PAD has greater mitochondrial impairment, increased reactive oxygen species, and increased fibrosis. In multiple small trials, walking exercise therapy did not consistently improve mitochondrial activity in people with PAD. In one 12-week randomized trial of people with PAD randomized to supervised exercise or control, supervised treadmill exercise increased treadmill walking time from 9.3 to 15.1 minutes, but simultaneously increased the proportion of angular muscle fibers, consistent with muscle denervation...Continue Reading

References

Mar 1, 1976·Acta Physiologica Scandinavica·B SaltinD Gollnick
Jul 1, 1992·Journal of Applied Physiology·W R HiattE P Brass
May 1, 1992·Neurology·J D EnglandW R Hiatt
May 1, 1992·Journal of Applied Physiology·A R CogganJ O Holloszy
Apr 1, 1995·Muscle & Nerve·J D EnglandJ G Regensteiner
May 1, 1997·The Journal of Nutrition·J Lexell
May 31, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S M RothM A Rogers
Jul 11, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·M R McGuiganW J Kraemer
Dec 12, 2001·Medicine and Science in Sports and Exercise·M R McGuiganW J Kraemer
Jun 19, 2002·Annals of Internal Medicine·Mary McGrae McDermottElizabeth Clark
Feb 15, 2003·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marcas M BammanGary R Hunter
May 12, 2005·Journal of Vascular Surgery·Christopher D AskewMark A Febbraio
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Elizabeth V MenshikovaBret H Goodpaster
Jul 4, 2006·Free Radical Biology & Medicine·Iraklis I PipinosStephen L Dodd
Aug 5, 2006·Molecular Pharmacology·Qingdong Ke, Max Costa
Oct 13, 2006·Archives of Internal Medicine·Mary M McDermottMichael H Criqui
Feb 27, 2007·Journal of Vascular Surgery·Lois A KillewichRobert R Wolfe
Mar 8, 2007·Journal of the American Geriatrics Society·Mary M McDermottMichael H Criqui
May 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Iraklis I PipinosGeorge P Casale
Oct 17, 2008·Physiological Reviews·Scott K Powers, Malcolm J Jackson
Feb 7, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Lex B VerdijkLuc J C van Loon
Apr 18, 2009·Nitric Oxide : Biology and Chemistry·Jason D AllenBrian H Annex
May 26, 2009·Ageing Research Reviews·Tim SnijdersLuc J C van Loon
Aug 8, 2009·Journal of the American College of Cardiology·Justin D AndersonChristopher M Kramer
Nov 3, 2009·Experimental Physiology·Scott K PowersErin E Talbert
Jan 5, 2010·Oxidative Medicine and Cellular Longevity·Kelsey Fisher-WellmanRichard J Bloomer
Feb 10, 2010·Medicine and Science in Sports and Exercise·Geoffrey A PowerCharles L Rice
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gregorio ValdezJoshua R Sanes
Jul 22, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dominik PestaErich Gnaiger
Aug 13, 2011·Journal of Applied Physiology·Frank W BoothMichael D Roberts
Aug 27, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Brian D DuschaBrian H Annex

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Jun 11, 2021·Circulation Research·Nicholas J Leeper, Naomi M Hamburg

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