Walking-related digital mobility outcomes as clinical trial endpoint measures: protocol for a scoping review.

BMJ Open
Ashley Marie PolhemusAnja Frei

Abstract

Advances in wearable sensor technology now enable frequent, objective monitoring of real-world walking. Walking-related digital mobility outcomes (DMOs), such as real-world walking speed, have the potential to be more sensitive to mobility changes than traditional clinical assessments. However, it is not yet clear which DMOs are most suitable for formal validation. In this review, we will explore the evidence on discriminant ability, construct validity, prognostic value and responsiveness of walking-related DMOs in four disease areas: Parkinson's disease, multiple sclerosis, chronic obstructive pulmonary disease and proximal femoral fracture. Arksey and O'Malley's methodological framework for scoping reviews will guide study conduct. We will search seven databases (Medline, CINAHL, Scopus, Web of Science, EMBASE, IEEE Digital Library and Cochrane Library) and grey literature for studies which (1) measure differences in DMOs between healthy and pathological walking, (2) assess relationships between DMOs and traditional clinical measures, (3) assess the prognostic value of DMOs and (4) use DMOs as endpoints in interventional clinical trials. Two reviewers will screen each abstract and full-text manuscript according to predefined ...Continue Reading

References

Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Jun 1, 1991·Physical Therapy·M E EastlackC L McGarvey
May 24, 2003·Clinical Biomechanics·Ugo H BuzziJack Heidel
Oct 31, 2003·Archives of Physical Medicine and Rehabilitation·Diane M WrisleyBarry Strasnick
Apr 20, 2006·Gait & Posture·Scott A England, Kevin P Granata
Jan 24, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Joe VergheseXiaonan Xue
May 19, 2007·Stroke; a Journal of Cerebral Circulation·Arlene SchmidSamuel S Wu
May 9, 2008·Journal of Evaluation in Clinical Practice·James E GrahamKenneth J Ottenbacher
May 17, 2008·Journal of the American Geriatrics Society·Joe VergheseRichard B Lipton
Jun 17, 2008·The Journal of Nervous and Mental Disease·Robert W MotlTimothy Vollmer
Nov 18, 2008·Gait & Posture·Jennifer L McGinleyMeg E Morris
Mar 5, 2009·Current Medical Research and Opinion·Donald E StullOlivier Chassany
Nov 18, 2009·Current Medical Research and Opinion·Matthew H Sutliff
Jul 8, 2010·Gait & Posture·Jonathan B Dingwell, Joseph P Cusumano
Sep 22, 2010·Implementation Science : IS·Danielle LevacKelly K O'Brien
Jan 6, 2011·JAMA : the Journal of the American Medical Association·Stephanie StudenskiJack Guralnik
May 3, 2011·Gait & Posture·John H HollmanRonald C Petersen
Apr 27, 2012·Disability and Rehabilitation·Deirdre DlugonskiRobert W Motl
Oct 3, 2012·Multiple Sclerosis : Clinical and Laboratory Research·Jiameng ZhangRobert Glanzman
Dec 20, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sue LordLynn Rochester
Oct 1, 2013·The Patient·Christine G KohnCraig I Coleman
Oct 18, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Sue LordLynn Rochester
May 9, 2014·Journal of Aging and Physical Activity·Addie MiddletonMichelle Lusardi
Jul 19, 2014·The European Respiratory Journal·Fabienne DobbelsUNKNOWN PROactive consortium
Aug 8, 2014·Medicine and Science in Sports and Exercise·David R BassettDana L Wolff
Nov 6, 2014·British Journal of Sports Medicine·Zeljko Pedišić, Adrian Bauman
May 23, 2015·IEEE Transactions on Bio-medical Engineering·Matthew A BrodieKim Delbaere
Apr 29, 2016·PloS One·Valerie A J BlockJeffrey M Gelfand
Apr 30, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Alberto J EspayUNKNOWN Movement Disorders Society Task Force on Technology
May 14, 2016·Journal of Neuroengineering and Rehabilitation·Silvia Del DinLynn Rochester
Jun 9, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Walter MaetzlerMalcolm Horne
Jul 28, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Silvia Del DinLynn Rochester
Jul 20, 2017·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Afolasade FakoladeMarcia Finlayson
Nov 10, 2017·Journal of Cardiopulmonary Rehabilitation and Prevention·Shweta GoreBara Alsalaheen
Apr 28, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Florian LipsmeierMichael Lindemann
Jun 30, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Michael GoldSara J Czaja
Jul 17, 2018·Drug Discovery Today·Philip BoehmeHubert Truebel

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Citations

Apr 22, 2021·Fortschritte der Neurologie-Psychiatrie·Max WuehrRoman Schniepp
Sep 25, 2021·Scientific Reports·Abolfazl SoltaniAnisoara Paraschiv-Ionescu
Oct 5, 2021·Expert Review of Medical Devices·Pietro PicernoGiovanni Morone

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