Walking Speed and Brain Glucose Uptake are Uncoupled in Patients with Multiple Sclerosis

Frontiers in Human Neuroscience
John H KindredThorsten Rudroff

Abstract

Motor impairments of the upper and lower extremities are common symptoms of multiple sclerosis (MS). While some peripheral effects like muscle weakness and loss of balance have been shown to influence these symptoms, central nervous system activity has not been fully elucidated. The purpose of this study was to determine if alterations in glucose uptake were associated with motor impairments in patients with multiple sclerosis. Eight patients with multiple sclerosis (four men) and eight sex matched healthy controls performed 15 min of treadmill walking at a self-selected pace, during which ≈322 MBq of the positron emission tomography (PET) glucose analog [(18)F]-fluorodeoxyglucose (FDG) was injected. Immediately after the cessation of walking, participants underwent PET imaging. Patients with MS had lower FDG uptake in ≈40% of the brain compared to the healthy controls (p FWE-corr < 0.001, q FDR-corr < 0.001, k e = 93851) and walked at a slower speed [MS, 1.1 (0.2), controls 1.4 (0.1), m/s, P = 0.014]. Within the area of lower FDG uptake 15 regions were identified. Of these 15 regions, 13 were found to have strong to moderate correlations to walking speed within the healthy controls (r > -0.75, P < 0.032). Within patients with ...Continue Reading

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Citations

Feb 4, 2016·Multiple Sclerosis International·Mithu Storoni, Gordon T Plant
Oct 21, 2015·NeuroImage·Henning Boecker, Alexander Drzezga
Jul 2, 2016·Multiple Sclerosis : Clinical and Laboratory Research·L Eduardo Cofré LizamaMary P Galea
Feb 6, 2017·Journal of Applied Physiology·Thorsten RudroffJohn H Kindred

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Methods Mentioned

BETA
infrared spectroscopy

Software Mentioned

MRIcron
SPM
marsbar
Statistical Parametric Mapping 8 ( SPM8 )
Analyze
SPSS
SPM8

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