Wall Shear Stress Directional Abnormalities in BAV Aortas: Toward a New Hemodynamic Predictor of Aortopathy?

Frontiers in Physiology
Janet LiuPhilippe Sucosky

Abstract

The bicuspid aortic valve (BAV) generates wall shear stress (WSS) abnormalities in the ascending aorta (AA) that may be responsible for the high prevalence of aortopathy in BAV patients. While previous studies have analyzed the magnitude and oscillatory characteristics of the total or streamwise WSS in BAV AAs, the assessment of the circumferential component is lacking despite its expected significance in this highly helical flow environment. This gap may have hampered the identification of a robust hemodynamic predictor of BAV aortopathy. The objective of this study was to perform a global and component-specific assessment of WSS magnitude, oscillatory and directional characteristics in BAV AAs. The WSS environments were computed in the proximal and middle convexity of tricuspid aortic valve (TAV) and BAV AAs using our previous valve-aorta fluid-structure interaction (FSI) models. Component-specific WSS characteristics were investigated in terms of temporal shear magnitude (TSM) and oscillatory shear index (OSI). WSS directionality was quantified in terms of mean WSS vector magnitude and angle, and angular dispersion index (Dα). Local WSS magnitude and multidirectionality were captured in a new shear magnitude and directionali...Continue Reading

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Jan 12, 2019·Current Opinion in Cardiology·Ali Fatehi HassanabadPaul W M Fedak
Jun 11, 2020·Cardiovascular Engineering and Technology·Diana M C de OliveiraDaniel M Espino
Apr 27, 2019·Frontiers in Physiology·Guillaume GoudotEmmanuel Messas
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Jun 15, 2021·Frontiers in Cardiovascular Medicine·Hail B KazikJoy Lincoln

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