Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial

Metabolism: Clinical and Experimental
Liya WuKlaus G Parhofer

Abstract

Walnut consumption is associated with reduced risk of coronary heart disease (CHD). We assessed the effect of walnuts on lipid and glucose metabolism, adipokines, inflammation and endothelial function in healthy Caucasian men and postmenopausal women ≥50years old. Forty subjects (mean±SEM: age 60±1years, BMI 24.9±0.6kg/m(2); 30 females) were included in a controlled, cross-over study and randomized to receive first a walnut-enriched (43g/d) and then a Western-type (control) diet or vice-versa, with each lasting 8weeks and separated by a 2-week wash-out. At the beginning and end of each diet phase, measurements of fasting values, a mixed meal test and an assessment of postprandial endothelial function (determination of microcirculation by peripheral artery tonometry) were conducted. Area under the curve (AUC), incremental AUC (iAUC) and treatment×time interaction (shape of the curve) were evaluated for postprandial triglycerides, VLDL-triglycerides, chylomicron-triglycerides, glucose and insulin. Compared with the control diet, the walnut diet significantly reduced non-HDL-cholesterol (walnut vs. control: -10±3 vs. -3±2mg/dL; p=0.025) and apolipoprotein-B (-5.0±1.3 vs. -0.2±1.1mg/dL; p=0.009) after adjusting for age, gender, BMI...Continue Reading

Associated Clinical Trials

Jul 21, 2017·Lenore Arab, PhD

References

Mar 4, 1993·The New England Journal of Medicine·J SabatéK D Lindsted
Jun 25, 2002·European Journal of Clinical Nutrition·M IwamotoM Kono
May 12, 2004·Circulation·Maria E OttoVirend Somers
Apr 15, 2006·Journal of Applied Physiology·Anju NohriaPeter Ganz
Oct 19, 2006·Journal of the American College of Cardiology·Berenice CortésEmilio Ros
Nov 28, 2006·The British Journal of Nutrition·John H Kelly, Joan Sabaté
Mar 27, 2007·The British Journal of Nutrition·Janine Mukuddem-PetersenZelda White
Jul 20, 2007·JAMA : the Journal of the American Medical Association·Børge G NordestgaardAnne Tybjaerg-Hansen
Aug 21, 2007·JAMA : the Journal of the American Medical Association·Erik IngelssonRamachandran S Vasan
May 17, 2008·Journal of Applied Physiology·Mandeep DhindsaHirofumi Tanaka
Jan 24, 2009·Journal of the American College of Cardiology·Jennifer G RobinsonTerry A Jacobson
May 22, 2009·The American Journal of Clinical Nutrition·Deirdre K Banel, Frank B Hu
Aug 6, 2009·Journal of Lipid Research·Claudia GlaserBerthold Koletzko
Dec 25, 2009·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·P Casas-AgustenchJ Salas-Salvadó
Jan 13, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Patricia López-UriarteJordi Salas-Salvadó
Jun 29, 2010·Metabolism: Clinical and Experimental·Sing-Chung LiC-Y Oliver Chen
Oct 19, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dick H J ThijssenDaniel J Green
Dec 16, 2010·European Journal of Clinical Nutrition·S KalgaonkarS E Karakas
Mar 23, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·N R T DamascenoE Ros
Oct 12, 2011·Journal of Agricultural and Food Chemistry·Katherine S RobbinsRonald B Pegg
Jul 1, 2010·Nutrients·Emilio Ros
Sep 14, 2012·Journal of Atherosclerosis and Thrombosis·Pavel Poredos, Mateja Kaja Jezovnik
Dec 26, 2012·Journal of the American College of Cardiology·Anette VarboBørge G Nordestgaard
Feb 22, 2013·The Journal of Nutrition·An PanFrank B Hu
Feb 26, 2013·The New England Journal of Medicine·Ramón EstruchUNKNOWN PREDIMED Study Investigators
Jun 4, 2013·Lipids in Health and Disease·Elisa WaldmannKlaus G Parhofer

❮ Previous
Next ❯

Citations

Sep 23, 2014·Metabolism: Clinical and Experimental·Liya Wu, Klaus G Parhofer
Jan 1, 2015·Metabolism: Clinical and Experimental·Olivia M FarrChristos S Mantzoros
Sep 20, 2016·Journal of Integrative Medicine·Nisha PanthRajendra Karki
Nov 9, 2016·Nutrition Research Reviews·Valérie LamantiaMay Faraj
Jun 29, 2017·Nutrients·Pablo Hernández-AlonsoJordi Salas-Salvadó
Jan 10, 2018·Journal of the American College of Nutrition·Mark HoustonMimi Guarneri
Sep 29, 2015·The Cochrane Database of Systematic Reviews·Nicole MartinKaren Rees
Jun 8, 2018·The Journal of Nutrition·Caroline E Childs
Jun 22, 2018·Diabetes/metabolism Research and Reviews·Lenore ArabDavid Elashoff
Feb 6, 2019·The American Journal of Clinical Nutrition·Alyssa M TindallKristina S Petersen
Apr 14, 2016·MMW Fortschritte der Medizin·Katharina Lechner, Klaus G Parhofer
Dec 20, 2018·Nutrients·Yoona KimPeter M Clifton
Aug 15, 2019·Antioxidants·Marius Emil RusuDaniela-Saveta Popa
May 26, 2017·Anais Da Academia Brasileira De Ciências·Bernardita MonsalveEduardo Fuentes
Jun 16, 2018·Frontiers in Nutrition·Fangxia GuanDerek M Huffman
Jan 11, 2019·Nutrients·Samantha MorgilloAlison M Coates
Dec 11, 2019·International Journal of Environmental Research and Public Health·Yoona KimPeter M Clifton
May 30, 2019·World Journal of Diabetes·Ishwarlal Jialal, Gurdeep Singh
Jan 17, 2020·Metabolites·Camila WeschenfelderAline Marcadenti
Mar 30, 2019·Genes & Nutrition·Mar Garcia-AloyCristina Andres-Lacueva
Apr 22, 2020·The British Journal of Nutrition·Elizabeth P NealeYasmine C Probst
May 7, 2016·Deutsches Ärzteblatt International·Klaus G Parhofer
Jun 17, 2021·Annals of Medicine·Danielle CahoonNanguneri Nirmala
Oct 27, 2021·Biomolecules & Therapeutics·Vijayakumar Natesan, Sung-Jin Kim

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.