Abstract
The toxicity of snake venom varies over time in some species. The venom of newborn and small juvenile snakes appears to be more potent than adults of the same species, and a bite from a snake that has not fed recently, such as one that has just emerged from hibernation, is more dangerous than one that has recently fed due to the larger volume of venom injected. Therefore, the potency of a snake's venom is typically determined using the LD50 or IC50 tests. In the present study, we evaluated the anti-tumor potential of snake venom from Walterinnesia aegyptia (WEV) on the human breast carcinoma cell line MDA-MB-231, as well as its effect on the normal mice peripheral blood mononuclear cells (PBMCs). This venom was used alone (WEV) or in combination with silica nanoparticles (WEV+NP). The IC50 values of WEV alone and WEV+NP in the MDA-MB-231 cells were determined to be 50 ng/ml and 20 ng/ml, respectively. Interestingly, at these concentrations, the venom did not affect the viability of normal human PBMCs. To investigate the in vivo effects of this venom further, three groups of mice were used (15 mice in each group): Group I was the control, Group II was subcutaneously injected with WEV, and Group III was injected with WEV+NP. Usin...Continue Reading
References
Apr 15, 1999·Nature Medicine·C Y WangA S Baldwin
Mar 23, 2002·Haemostasis·F S MarklandR Sposto
Mar 5, 2003·Cellular and Molecular Life Sciences : CMLS·G Barratt
Nov 25, 2003·Blood·Ching-Hu ChungTur-Fu Huang
Dec 6, 2003·Science·Anne J RidleyAlan Rick Horwitz
Jun 8, 2004·Current Cancer Drug Targets·JianYu Rao, Ning Li
Jul 13, 2004·Biochimica Et Biophysica Acta·Michele A WozniakPatricia J Keely
Aug 2, 2005·Cancer Science·Daisuke YamazakiTadaomi Takenawa
Sep 22, 2005·Nature Reviews. Immunology·Michael Karin, Florian R Greten
May 25, 2006·Annals of Medicine·Michiaki Kohno, Jacques Pouyssegur
Sep 15, 2007·Toxicon : Official Journal of the International Society on Toxinology·Isabela Batista OlivaChristina Barja-Fidalgo
Jan 4, 2008·Blood·Gamal BadrYolande Richard
Aug 25, 2009·Trends in Immunology·Shrimati Datta, Nora Sarvetnick
Sep 15, 2009·Toxicology and Applied Pharmacology·M DingA A Shvedova
Jan 22, 2010·Archives of Pharmacal Research·Mi Hee ParkJin Tae Hong
Jun 23, 2011·PloS One·Angela AlamaMassimo Romani
Sep 3, 2011·PloS One·Victor KueteThomas Efferth
Citations
Dec 15, 2012·Apoptosis : an International Journal on Programmed Cell Death·Gamal BadrDouaa Sayed
Dec 20, 2012·PloS One·Gamal BadrAhmed M El-Toni
Jan 21, 2014·Homeopathy : the Journal of the Faculty of Homeopathy·Paolo BellaviteAnita Conforti
Apr 23, 2014·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Iris R BellJohn Ives
Jul 21, 2015·Cellular Signalling·Mohamed H MahmoudMahmoud Shaaban Mohamed
Jan 11, 2013·Oxidative Medicine and Cellular Longevity·Douaa SayedGamal Badr
Jul 3, 2013·Free Radical Biology & Medicine·Gamal BadrDanny M Rabah
Aug 25, 2015·Toxicology and Applied Pharmacology·Sae-Kwang KuJong-Sup Bae
Sep 10, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Quan JinJi-Xing Nan
Feb 17, 2017·European Journal of Haematology·Pilar de la Puente, Abdel Kareem Azab
Oct 4, 2016·International Journal of Immunopathology and Pharmacology·Mohamed H MahmoudNashwa A El Shinnawy
Apr 24, 2018·Molecular Reproduction and Development·Gamal BadrMohamed H Mahmoud
Jul 15, 2017·Journal of Cellular Biochemistry·Min ZhangDaling Zhu
Nov 23, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Gamal BadrMohamed H Mahmoud
Feb 8, 2018·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Tarek Mohamed Abd El-AzizMichel De Waard
Apr 25, 2019·Nutrition and Cancer·Gamal BadrMohamed H Mahmoud
Jan 31, 2016·Journal of Cellular Physiology·Gamal BadrOlivier Garraud
Jan 15, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Nagwa Abo El-MaaliGamal Abd El Wahab
Nov 15, 2016·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Svetlana DinićMelita Vidaković
Dec 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jia HeShilin Yang
Sep 16, 2015·BMC Immunology·Ahmad A Al GhamdiOlivier Garraud
Jul 19, 2016·Toxicology Research·Jin ZhangXianqing Zhou
Nov 21, 2017·Environmental Science and Pollution Research International·Jianhui LiuZhiwei Sun
Oct 25, 2020·International Journal of Molecular Sciences·Tarek Mohamed Abd El-AzizMichel De Waard
Feb 23, 2021·Saudi Journal of Biological Sciences·Eman A SayedSalman Alamery
Mar 14, 2018·Bioorganic Chemistry·Gamal BadrNagwa Abo El-Maali