Wandering pathways in the regulation of innate immunity and inflammation.

Journal of Autoimmunity
Alberto Mantovani

Abstract

Tumor-associated macrophages (TAM) have served as a paradigm of cancer-related inflammation. Moreover, investigations on TAM have led to the dissection of macrophage plasticity and polarization and to the discovery and analysis of molecular pathways of innate immunity, in particular cytokines, chemokines and PTX3 as a prototypic fluid phase pattern recognition molecule. Mechanisms of negative regulation are complex and include decoy receptors, receptor antagonists, anti-inflammatory cytokines and the signalling regulator IL-1R8. In this review, topics and open issues in relation to regulation of innate immunity and inflammation are discussed: 1) how macrophage and neutrophil plasticity and polarization underlie diverse pathological conditions ranging from autoimmunity to cancer and may pave the way to innovative diagnostic and therapeutic approaches; 2) the key role of decoy receptors and negative regulators (e.g. IL-1R2, ACKR2, IL-1R8) in striking a balance between amplification of immunity and resolution versus uncontrolled inflammation and tissue damage; 3) role of humoral innate immunity, illustrated by PTX3, in resistance against selected microbes, regulation of inflammation and immunity and tissue repair, with implication...Continue Reading

Citations

Aug 18, 2018·Journal of Cellular and Molecular Medicine·Arcangelo LisoMassimo Conese
Nov 7, 2019·Current Pharmaceutical Design·Melek Kechida
Jul 28, 2018·Clinical Reviews in Allergy & Immunology·Carlo Selmi
Dec 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Irena KaplanovRon N Apte
Oct 8, 2020·Current Atherosclerosis Reports·Antonio V Sterpetti
Feb 16, 2021·Frontiers in Aging Neuroscience·Johannes BoltzeMarietta Zille
Mar 12, 2021·Bioscience Reports·Maoling YuanJingting Jiang
May 30, 2021·Advanced Materials·Jun-Long LiangXian-Zheng Zhang

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