Warfarin-induced changes in procoagulant and anticoagulant proteins

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Y Stirling

Abstract

Dicoumarol was found to be the causative agent of a haemorrhagic disease in cattle following the ingestion of spoiled sweet clover. Vitamin K deficiency in chickens caused bleeding. Dicoumarol was later determined to be a vitamin K antagonist. A more potent form of the drug was produced synthetically and, following its initial use as rat poison, was recognized as a potential anti-thrombotic treatment in humans. The mode of action of a coumarin derivative (i.e. warfarin) is described. The overall effect of high-dose and low-dose warfarin and the possibility of a transient state of hypercoagulability on the introduction and withdrawal of treatment is considered.

Citations

Nov 10, 2009·Wiener medizinische Wochenschrift·Werner Streif
Jan 28, 2009·Apoptosis : an International Journal on Programmed Cell Death·Hagit GrimbergIlan Ziv
Feb 19, 2009·Cell Research·Avi CohenIlan Ziv
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Syed M QadriFlorian Lang
Jan 19, 2016·Journal of Thrombosis and Thrombolysis·Edith A NutescuAnn Wittkowsky
May 6, 2016·Journal of Thrombosis and Thrombolysis·Edith A NutescuAnn Wittkowsky
Sep 1, 1999·American Journal of Hematology·T E WarkentinD P Lillicrap
Sep 16, 2017·Journal of Thrombosis and Thrombolysis·Tammy J BungardBruce Ritchie
Dec 22, 1999·The American Journal of Gastroenterology·P DraganovG Portwood
Aug 27, 2005·Orthopedics·Lisa M Taylor, Kelly M Smith

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